HIV-1 protease-IN-8
HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant.
For research use only. We do not sell to patients.
- CAS No.: 2925287-55-2
- Formula: C25H35N3O5S
- Molecular Weight:489.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HIV-1 0.32 nM (IC50) |
HIV-1 (NL4-3) 0.29 μM (EC50) |
HIV-1 (MDR) 1.90 μM (EC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>200 μM
Compound: 34b
|
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 37120996] |
Chemical Information
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CAS No. 2925287-55-2
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Molecular Weight 489.63
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Formula C25H35N3O5S
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SMILES
O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(C2=CC=C(C=C2)O)=O)[C@@H]3CCNC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)