2925287-55-2
Chemical Structure
HIV-1 protease-IN-8
- CAS No.: 2925287-55-2
- Formula:C25H35N3O5S
- Molecular Weight:489.63
IUPAC Name: (R)-N-((2S,3R)-3-hydroxy-4-((4-hydroxy-N-isobutylphenyl)sulfonamido)-1-phenylbutan-2-yl)pyrrolidine-3-carboxamide
InChIKey: IBZXXQSXINCLJJ-FGCOXFRFSA-N
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(C2=CC=C(C=C2)O)=O)[C@@H]3CCNC3
Biological Activity: HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant[1].
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HIV-1 protease-IN-8 | HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant. | |||||||||||||||||||||
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Keywords
