1. GPCR/G Protein
  2. Adenosine Receptor
  3. Ticlopidine hydrochloride

Ticlopidine hydrochloride 

Cat. No.: HY-B0153A Purity: 99.99%
Handling Instructions

Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.

For research use only. We do not sell to patients.

Ticlopidine hydrochloride Chemical Structure

Ticlopidine hydrochloride Chemical Structure

CAS No. : 53885-35-1

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10 mM * 1  mL in DMSO USD 55 In-stock
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Description

Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM. Target: Adenosine diphosphate (ADP) Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet aggregation with IC50 of ~2 μM in men. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route. Ticlopidine hydrochloride, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme.

Clinical Trial
Molecular Weight

300.25

Formula

C₁₄H₁₅Cl₂NS

CAS No.

53885-35-1

SMILES

ClC1=CC=CC=C1CN2CCC3=C(C=CS3)C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (166.53 mM; Need ultrasonic)

DMSO : 50 mg/mL (166.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3306 mL 16.6528 mL 33.3056 mL
5 mM 0.6661 mL 3.3306 mL 6.6611 mL
10 mM 0.3331 mL 1.6653 mL 3.3306 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.99%

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Keywords:

TiclopidineAdenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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Product Name:
Ticlopidine hydrochloride
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HY-B0153A
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