2. Peptides
  3. BIM-23027

BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism.

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BIM-23027 Chemical Structure

BIM-23027 Chemical Structure

CAS No. : 78981-49-4

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BIM-23027 Related Antibodies

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Description

BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2].

IC50 & Target

EC50: 0.32 nM (sst2)[2]
In Vitro

BIM-23027 (10, 50, and 100 nM; 90 min) significantly increases the level of dopamine[1].
BIM-23027 (50 nM; 15 min prior to SRIF (100 nM)) significantly attenuates the actions of the naturally-occurring peptide[1].
BIM-23027 (30 nM; 30 min) carbachol-stimulated increases in basal SCC by 60-70%, with an EC50 value of 0.29 nM[2].
BIM-23027 interacts with a sub-population of [125I]Tyr11-SRIF binding sites in rat colonic mucosal membranes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIM-23027 Related Antibodies
Molecular Weight

794.94

Formula

C43H54N8O7
CAS No.
Sequence Shortening

Cyclo[{(NMe)Ala}-FWKTF]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIM-2302778981-49-4BIM23027BIM 23027OthersInhibitorinhibitorinhibit

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