Allergin-1 Protein, Mouse (HEK293, Fc)

Allergin-1 protein, an immunoglobulin-like receptor, inhibits mast cell degranulation and suppresses hypersensitivity reactions. It interacts with tyrosine-phosphorylated proteins, such as PTPN6, PTPN11, and INPP5D, to fine-tune mast cell responses. Allergin-1 plays a pivotal role in regulating allergic reactions and hypersensitivity responses. Allergin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Allergin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Allergin-1 Protein, Mouse (HEK293, Fc) is 150 a.a., with molecular weight of 55-80 KDa.

Allergin-1 protein, an immunoglobulin-like receptor, assumes an inhibitory role in the degranulation process of mast cells. Functioning as a negative regulator, it plays a crucial part in mitigating IgE-mediated mast cell activation and suppressing type I immediate hypersensitivity reactions. Allergin-1 exists as a monomer, and it interacts specifically with tyrosine-phosphorylated proteins such as PTPN6, PTPN11, and INPP5D. This intricate molecular interaction underscores the pivotal role of Allergin-1 in fine-tuning mast cell responses, contributing to the intricate regulatory mechanisms that modulate allergic reactions and hypersensitivity responses.

Mouse

HEK293

C-hFc

Q3TB92 (M1-S150)

380732  [NCBI]

55-80 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.