2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX-IN-11

hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells.

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hCAIX-IN-11 Chemical Structure

hCAIX-IN-11 Chemical Structure

CAS No. : 2497504-81-9

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hCAIX-IN-11 Related Antibodies

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

IC50 & Target

Ki: 32.7 nM (hCA IX), 623.5 nM (hCA XII), ＞10000 nM nM (hCA I), ＞10000 (hCA II)[1]
Molecular Weight

406.82

Formula

C21H15ClN4O3
CAS No.
SMILES

N#CC1=CC=C(CN2N=NC(COC3=CC=C(C(O4)=C3)C(CCl)=CC4=O)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCAIX-IN-11 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-112497504-81-9Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrasetransmembranebiomarkertumorInhibitorinhibitorinhibit

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