1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAIX-IN-11

hCAIX-IN-11 

Cat. No.: HY-147828
Handling Instructions

hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells.

For research use only. We do not sell to patients.

hCAIX-IN-11 Chemical Structure

hCAIX-IN-11 Chemical Structure

CAS No. : 2497504-81-9

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Description

hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

IC50 & Target

Ki: 32.7 nM (hCA IX), 623.5 nM (hCA XII), >10000 nM nM (hCA I), >10000 (hCA II)[1]

Molecular Weight

406.82

Formula

C21H15ClN4O3

CAS No.
SMILES

N#CC1=CC=C(CN2N=NC(COC3=CC=C(C(O4)=C3)C(CCl)=CC4=O)=C2)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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hCAIX-IN-11
Cat. No.:
HY-147828
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