Brinzolamide hydrochloride
Based on 7 publication(s) in Google Scholar
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 150937-43-2
- Formule: C12H22ClN3O5S3
- Masse moléculaire:419.97
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Brinzolamide hydrochloride
More- Mater Today Bio. 2025 Aug 11:34:102179. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Anal Chem. 2020 Dec 15;92(24):15745-15756. [Abstract]
- J Pharm Biomed Anal. 2021 Feb 20:195:113870. [Abstract]
- J Pharm Innov. 2025 Oct 14;20(5):1-22.
- ETH Zurich. 2020 Dec.
Activité biologique
|
hCA II 3.2 nM (IC50) |
The pharmacokinetic parameters of Brinzolamide hydrochloride in rabbits[1].
| Intracameral Administration (4.5 mg) | Intracameral Administration (4.5 mg) | Topical Administration (500 mg) | Topical Administration (500 mg) | |
| PK Parameters | Aqueous Humor | Iris-Ciliary Body | Aqueous Humor | Iris-Ciliary Body |
| Tmax (h) | 0.08 | 0.5 | 1 | 0.25 |
| Cmax (ng/mL, ng/g) | 11,050 | 1964 | 408 | 1245 |
| Terminal t1/2 (h) | 3.4 | 13 | 2 | 13.6 |
| AUC0-24h (h*ng/mL, h*ng/g) | 17,780 | 7725 | 1896 | 11414 |
| AUC0-∞ (h*ng/mL, h*ng/g) | 17,836 | 8839 | 1955 | 16628 |
| Dose-normalized AUC0-∞ (h*/mL, h*/g) | 4 | 2 | 0.004 | 0.03 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rabbits[2]
-
Dosage:7.5 mg, 12 mg
-
Administration:Implant placed in the episcleral space
-
Result:Resulted in a significant IOP reduction of 4.6 mmHg on days 10-28, with concentrations of 12 mg.
Chemical Information
-
CAS No. 150937-43-2
-
Masse moléculaire 419.97
-
Formule C12H22ClN3O5S3
-
SMILES
O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O.Cl[H]
-
Synonyms
AL-4862 hydrochloride
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Mater Today Bio
Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment. [Abstract]2025 Aug 11:34:102179. PMID: 40838214 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Anal Chem
Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. [Abstract]2020 Dec 15;92(24):15745-15756. PMID: 33225709 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569 -
-
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brinzolamide hydrochloride Related Classifications
HY-B0588A Related Classifications
Powered by Bioz