MMGT1 Antibody (YA8364)
(Synonyms: EMC5; TMEM32)MMGT1 Antibody (YA8364) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MMGT1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
MMGT1 Antibody (YA8364) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MMGT1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 14.5 kDa
Full length human recombiant protein of human MMGT1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MMGT1 is a Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane,Golgi apparatus membrane,Early endosome membrane
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Isoforms & Post-Translational Modification
Q8N4V1 has two isomers: Q8N4V1-1: 14686 Da (predicted); Q8N4V1-2: 21881 Da (predicted).
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Subunit
Component of the ER membrane protein complex (EMC)
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SwissProt ID
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Synonyms
EMC5; TMEM32
Documentation
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