1. MAPK/ERK Pathway
  2. Raf
  3. SHR902275

SHR902275 

Cat. No.: HY-144269
Handling Instructions

SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.

For research use only. We do not sell to patients.

SHR902275 Chemical Structure

SHR902275 Chemical Structure

CAS No. : 2695506-82-0

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Description

SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively[1].

IC50 & Target[1]

c-Raf

1.6 nM (IC50)

BRafV600E

5.7 nM (IC50)

BRAFWT

10 nM (IC50)

Molecular Weight

512.48

Formula

C26H23F3N4O4

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SHR902275
Cat. No.:
HY-144269
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