2695506-82-0
Chemical Structure
SHR902275
- CAS No.: 2695506-82-0
- Formula:C26H23F3N4O4
- Molecular Weight:512.48
IUPAC Name: N-(4-methyl-3-(4-oxo-2',3',4,5,5',6'-hexahydro-3H-spiro[benzo[b][1,4]oxazepine-2,4'-pyran]-8-yl)phenyl)-5-(trifluoromethyl)pyridazine-3-carboxamide
InChIKey: LRTINOCIDJSJPY-UHFFFAOYSA-N
SMILES: O=C(C1=NN=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(NC(CC5(CCOCC5)O4)=O)C=C3)=C2
Biological Activity: SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SHR902275 | 99.80% | SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively. | ||||||||||||||||||||
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Keywords
