Licopyranocoumarin
Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities.
For research use only. We do not sell to patients.
- CAS No.: 117038-80-9
- Formula: C21H20O7
- Molecular Weight:384.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP3A4 32 μM (IC50) |
Licopyranocoumarin (0.3-3 μM; 48 hours) markedly blocks MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK[1].
Licopyranocoumarin (0.3-3 μM; 36 hours) inhibits MPP+-induced JNK activation through the suppression of reactive oxygen species (ROS) generation, thereby inhibiting MPP+-induced neuronal PC12D cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12D cell
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Concentration:0.3 μM, 1 μM, 3 μM
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Incubation Time:48 hours
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Result:Inhibited MPP+-induced cell death.
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Cell Line:PC12D cell
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Concentration:0.3 μM, 1 μM, 3 μM
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Incubation Time:36 hours
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Result:Attenuated JNK activity induced by MPP+.
Chemical Information
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CAS No. 117038-80-9
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Molecular Weight 384.38
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Formula C21H20O7
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SMILES
O=C1OC2=CC(OC(CO)(CC3)C)=C3C(OC)=C2C=C1C4=CC=C(C=C4O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Takahiro Fujimaki, et al. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. PLoS One. 2014 Jun 24;9(6):e100395. [Content Brief]
[2]. Sachiko Tsukamoto, et al. CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull. 2005 Oct;28(10):2000-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Licopyranocoumarin Related Classifications
HY-119804 Related Classifications
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