EGFR-IN-177
EGFR-IN-177 is a potent EGFR inhibitor with IC50s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3062177-59-4
- Formula: C27H36N8O3
- Molecular Weight:520.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
|
EGFR L858R 0.32 nM (IC50) |
EGFRL858R/T790M 1.04 nM (IC50) |
EGFR L858R/T790M/C797S 0.65 nM (IC50) |
EGFRd746-750 0.67 nM (IC50) |
EGFRWT 0.38 nM (IC50) |
EGFR-IN-177 (Example 54) inhibits EGFR phosphorylation in PC-9, H1975 and A431 cells with IC50s of 0.67, 0.94 and 10.66 nM[1].
EGFR-IN-177 (5 days) inhibits in PC-9, H1975 and A431 cells proliferation with IC50s of 0.78, 0.99 and 0.41 nM[1].
EGFR-IN-177 (3 days) inhibits proliferation of BaF3 cells with engineered EGFR L858R/T790M/C797S, EGFR L858R/C797S and EGFR d746-750/T790M transgene with IC50s of 0.55, 0.06 and 0.55 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3062177-59-4
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Molecular Weight 520.63
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Formula C27H36N8O3
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SMILES
OC[C@@H](N1C2=C(/C=C/C(C3=CC(C4=C(N(N=C4C)C)O[C@H](CN(C2)C)C)=N5)=NNC3=C5C)C(OCC)=N1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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