3062177-59-4
Chemical Structure
EGFR-IN-177
- CAS No.: 3062177-59-4
- Formula:C27H36N8O3
- Molecular Weight:520.63
InChIKey: IBMIIAILYKKSRC-IGXNXKSNSA-N
SMILES: OC[C@@H](N1C2=C(/C=C/C(C3=CC(C4=C(N(N=C4C)C)O[C@H](CN(C2)C)C)=N5)=NNC3=C5C)C(OCC)=N1)C
Biological Activity: EGFR-IN-177 is a potent EGFR inhibitor with IC50s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer[1].
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EGFR-IN-177 | EGFR-IN-177 is a potent EGFR inhibitor with IC50s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
