2. Immunology/Inflammation
  3. COX
  4. Florifenine

Florifenine is a selective cyclooxygenase (COX) inhibitor with anti-inflammatory activity. Florifenine inhibits TXB2 in human whole blood with an IC50 of 32.5 nM. Florifenine exhibits anti-inflammatory effects in ear oedema. Florifenine inhibits neutrophil migration and reduces PGE2 levles in the inflamed ears. Florifenine inhibits leukocyte migration and PGE2 levels in the air pouch inflammation induced by Zymosan (HY-159069). Florifenine can be used for anti-inflammatory research.

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Florifenine

Florifenine Chemical Structure

CAS No. : 83863-79-0

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Florifenine Related Antibodies

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Description

Florifenine is a selective cyclooxygenase (COX) inhibitor with anti-inflammatory activity. Florifenine inhibits TXB2 in human whole blood with an IC50 of 32.5 nM. Florifenine exhibits anti-inflammatory effects in ear oedema. Florifenine inhibits neutrophil migration and reduces PGE2 levles in the inflamed ears. Florifenine inhibits leukocyte migration and PGE2 levels in the air pouch inflammation induced by Zymosan (HY-159069). Florifenine can be used for anti-inflammatory research[1].

Molecular Weight

429.43

Formula

C23H22F3N3O2
CAS No.
SMILES

FC(F)(F)C1=CC=C2C(NC3=C(C=CC=C3)C(OCCN4CCCC4)=O)=CC=NC2=C1
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Purity & Documentation
References
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Florifenine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Florifenine83863-79-0COXCyclooxygenasecyclooxygenaseanti-inflammatoryArachidonic acid12-O-tetradecanoylphorbol 13-acetateear oedemaneutrophilPGE2leukocyteZymosanInhibitorinhibitorinhibit

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