2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. LUF7346

LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM.

For research use only. We do not sell to patients.

LUF7346

LUF7346 Chemical Structure

CAS No. : 1821638-40-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Based on 1 publication(s) in Google Scholar

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Description

LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
12 μM
Compound: 7f
Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hr
Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hr
[PMID: 26519929]
Molecular Weight

411.25

Formula

C20H15BrN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC=C3Br)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4316 mL 12.1581 mL 24.3161 mL
5 mM 0.4863 mL 2.4316 mL 4.8632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4316 mL 12.1581 mL 24.3161 mL 60.7903 mL
5 mM 0.4863 mL 2.4316 mL 4.8632 mL 12.1581 mL
10 mM 0.2432 mL 1.2158 mL 2.4316 mL 6.0790 mL
15 mM 0.1621 mL 0.8105 mL 1.6211 mL 4.0527 mL
20 mM 0.1216 mL 0.6079 mL 1.2158 mL 3.0395 mL
25 mM 0.0973 mL 0.4863 mL 0.9726 mL 2.4316 mL
30 mM 0.0811 mL 0.4053 mL 0.8105 mL 2.0263 mL
40 mM 0.0608 mL 0.3040 mL 0.6079 mL 1.5198 mL
50 mM 0.0486 mL 0.2432 mL 0.4863 mL 1.2158 mL
60 mM 0.0405 mL 0.2026 mL 0.4053 mL 1.0132 mL
80 mM 0.0304 mL 0.1520 mL 0.3040 mL 0.7599 mL
100 mM 0.0243 mL 0.1216 mL 0.2432 mL 0.6079 mL
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LUF7346 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LUF73461821638-40-7LUF 7346LUF-7346Potassium ChannelKcsAInhibitorinhibitorinhibit

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