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Cat. No.: HY-148116

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DN02

Name: DN02
Brand: MedChemExpress
SKU: HY-148116
Price: 195.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Customer Review

Based on 1 Customer Validation

DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (K_i=32 nM), which is 30-fold more affinity than BRD8 (2) (K_i>1000 nM).

For research use only. We do not sell to patients.

Purity : 98.68%
CAS No.: 3055009-00-9
Formula: C₂₂H₂₄FN₃O₃
Molecular Weight:397.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DN02 Chemical Structure

CAS No.: 3055009-00-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (K_i=32 nM), which is 30-fold more affinity than BRD8 (2) (K_i>1000 nM)^[1].

All Epigenetic Reader Domain Isoforms :

In Vitro

DN02 has (1 nM-100 μM) low nM AlphaScreen with IC₅₀ value of 48 nM, with high selectivity over BRD9 and BRD4 in biochemical AlphaScreen assays^[1].
DN02 (32 nM) has minimal off-target engagement across the bromodomain family, with modest activity against CBP/P300^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3055009-00-9
Appearance Solid
Molecular Weight 397.44
Formula C₂₂H₂₄FN₃O₃
Color White to yellow
SMILES

O=C1N(C)C=C(C2=C(OC)C=C(CN3CC(N)C3)C=C2OC)C4=C1C=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (251.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5161 mL

12.5805 mL

25.1610 mL

5 mM

0.5032 mL

2.5161 mL

5.0322 mL

10 mM

0.2516 mL

1.2581 mL

2.5161 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Remillard D, et, al. Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5161 mL	12.5805 mL	25.1610 mL	62.9026 mL
	5 mM	0.5032 mL	2.5161 mL	5.0322 mL	12.5805 mL
	10 mM	0.2516 mL	1.2581 mL	2.5161 mL	6.2903 mL
	15 mM	0.1677 mL	0.8387 mL	1.6774 mL	4.1935 mL
	20 mM	0.1258 mL	0.6290 mL	1.2581 mL	3.1451 mL
	25 mM	0.1006 mL	0.5032 mL	1.0064 mL	2.5161 mL
	30 mM	0.0839 mL	0.4194 mL	0.8387 mL	2.0968 mL
	40 mM	0.0629 mL	0.3145 mL	0.6290 mL	1.5726 mL
	50 mM	0.0503 mL	0.2516 mL	0.5032 mL	1.2581 mL
	60 mM	0.0419 mL	0.2097 mL	0.4194 mL	1.0484 mL
	80 mM	0.0315 mL	0.1573 mL	0.3145 mL	0.7863 mL
	100 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.6290 mL

Bioz

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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DN02

All Epigenetic Reader Domain Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

DN02 Related Classifications

HY-148116 Related Classifications

Bioz

Keywords

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