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Art. -Nr.: HY-179635

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GSTO1-IN-6

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC₅₀ of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC₅₀ of 1.9 μM) and IL-18 (IC₅₀ of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases.

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CAS. Nr.: 3114128-67-2
Formel: C₁₆H₁₄F₃N₃OS
Molecular Weight:353.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

GSTO1-IN-6 Chemical Structure

CAS. Nr.: 3114128-67-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

GSTO1

457 nM (IC₅₀)

IL-1β

IL-18

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

GSTO1-IN-6 (compound A13) (1 μM; 5-60 minutes) demonstrates good metabolic stability in human and rat liver microsomes and good permeability in Caco-2 cells^[1].
GSTO1-IN-6 (2-10 μM; for 2 h) inhibits LPS- and Nigericin (HY-127019)-induced IL-1β secretion in mouse BMDMs^[1].
GSTO1-IN-6 (16 hours) inhibits LPS- and Nigericin-induced IL-1β and IL-18 release in human PBMC-derived macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	C_max	AUC_0-t	T_1/2	T_max	F
Mice^[1]	1 mg/kg	i.v.	文献审核	175 ng/mL	55.7 ng·h/mL	0.448 h	0.083 h	/
Mice^[1]	10 mg/kg	i.p.	文献审核	817 ng/mL	199 ng·h/mL	0.261 h	0.083 h	34.3 %
Mice^[1]	10 mg/kg	p.o.	文献审核	85.9 ng/mL	37 ng·h/mL	0.7 h	0.194 h	6.69 %

Chemical Information

CAS. Nr. 3114128-67-2
Molecular Weight 353.36
Formel C₁₆H₁₄F₃N₃OS
SMILES

O=C(N1CCC[C@@H]1C2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)C=C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun Y, et al. Discovery of Potent, Allosteric GSTO1 Covalent Inhibitors with a New Binding Mode. J Med Chem. 2025;68(22):24075-24093. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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GSTO1-IN-6

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GSTO1-IN-6 Related Classifications

HY-179635 Related Classifications