GSTO1-IN-6

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases.

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  • CAS. Nr.: 3114128-67-2
  • Formel: C16H14F3N3OS
  • Molecular Weight:353.36
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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