country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-179635

Copy Link Print Information

GSTO1-IN-6

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC₅₀ of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC₅₀ of 1.9 μM) and IL-18 (IC₅₀ of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3114128-67-2
화학식: C₁₆H₁₄F₃N₃OS
분자량:353.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

GSTO1-IN-6 Chemical Structure

CAS No.: 3114128-67-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

GSTO1

457 nM (IC₅₀)

IL-1β

IL-18

All Interleukin Related Isoforms :

In Vitro

GSTO1-IN-6 (compound A13) (1 μM; 5-60 minutes) demonstrates good metabolic stability in human and rat liver microsomes and good permeability in Caco-2 cells^[1].
GSTO1-IN-6 (2-10 μM; for 2 h) inhibits LPS- and Nigericin (HY-127019)-induced IL-1β secretion in mouse BMDMs^[1].
GSTO1-IN-6 (16 hours) inhibits LPS- and Nigericin-induced IL-1β and IL-18 release in human PBMC-derived macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	C_max	AUC_0-t	T_1/2	T_max	F
Mice^[1]	1 mg/kg	i.v.	文献审核	175 ng/mL	55.7 ng·h/mL	0.448 h	0.083 h	/
Mice^[1]	10 mg/kg	i.p.	文献审核	817 ng/mL	199 ng·h/mL	0.261 h	0.083 h	34.3 %
Mice^[1]	10 mg/kg	p.o.	文献审核	85.9 ng/mL	37 ng·h/mL	0.7 h	0.194 h	6.69 %

Chemical Information

CAS No. 3114128-67-2
분자량 353.36
화학식 C₁₆H₁₄F₃N₃OS
SMILES

O=C(N1CCC[C@@H]1C2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)C=C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. Discovery of Potent, Allosteric GSTO1 Covalent Inhibitors with a New Binding Mode. J Med Chem. 2025;68(22):24075-24093. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GSTO1-IN-6

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GSTO1-IN-6 Related Classifications

HY-179635 Related Classifications