HER2-IN-20
HER2-IN-20 (compound 32) is a potent and selective HER2WT and HER2YVMA inhibitor with IC50 values of 49, 42 nM, respectively. HER2-IN-20 has the potential for the research of non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Formula: C30H27ClFN7O2
- Molecular Weight:572.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
HER2(WT) 49 nM (IC50) |
HER2 YVMA 42 nM (IC50) |
EGFR (WT) 4584 nM (IC50) |
Chemical Information
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Molecular Weight 572.03
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Formula C30H27ClFN7O2
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SMILES
C=CC(N1[C@@]2([H])C[C@H](N3N=C(C4=CC(F)=C(OC5=CC=C6N(C)C=NC6=C5)C(Cl)=C4)C7=C(C)N=CN=C73)C[C@]1([H])CC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HER2-IN-20 Related Classifications
HY-163657 Related Classifications
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