ROMK-IN-32
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM.
For research use only. We do not sell to patients.
- CAS No.: 1914944-54-9
- Formula: C24H28N4O5
- Molecular Weight:452.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.035 μM
Compound: 32
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Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay
Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay
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[PMID: 28431879] |
| HEK293 | IC50 |
21.6 μM
Compound: 32
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Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
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[PMID: 28431879] |
ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats[1].
ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1914944-54-9
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Molecular Weight 452.50
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Formula C24H28N4O5
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SMILES
O=C1N(C(C=C2)=NN(C)C2=O)CCC13CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ROMK-IN-32 Related Classifications
HY-124687 Related Classifications
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