1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ROMK-IN-32

ROMK-IN-32 

Cat. No.: HY-124687
Handling Instructions

ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM.

For research use only. We do not sell to patients.

ROMK-IN-32 Chemical Structure

ROMK-IN-32 Chemical Structure

CAS No. : 1914944-54-9

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Description

ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM[1].

In Vitro

ROMK-IN-32 exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model[1].
ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats[1].
ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

452.50

Formula

C₂₄H₂₈N₄O₅

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ROMK-IN-32
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HY-124687
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