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Cat. No.: HY-181896S

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PPARγ agonist-23

PPARγ agonist-23 (Compound 9) is an orally active PPARγ agonist with an EC₅₀ of 0.32 μM. PPARγ agonist-23 improves hepatic triglyceride levels, reduces scores of steatosis and hepatocellular ballooning, and decreases the total activity score of non-alcoholic steatohepatitis (NASH). PPARγ agonist-23 can be used for the research of non-alcoholic steatohepatitis.

For research use only. We do not sell to patients.

Formula: C₂₈H₁₈D₇NO₇S
Molecular Weight:526.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PPARγ agonist-23 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PPARγ

0.32 μM (EC₅₀)

All PPAR Isoforms :

In Vitro

PPARγ agonist-23 activates PPARγ in HEK293 cells with an EC₅₀ of 0.32 ± 0.04 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-24	T_max	T_1/2
Rat^[1]	15 mg/kg	p.o.	1693 ± 339 ng/mL	8711 ± 871 ng·h/mL	1.60 ± 0.13 h	2.25 ± 0.45 h

In Vivo

PPARγ agonist-23 (25 mg/kg, p.o., once daily) significantly ameliorates symptoms in mouse models of non-alcoholic steatohepatitis (NASH)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male; NASH induced via high-fat diet and streptozotocin)^[1]
Dosage:

25 mg/kg
Administration:

p.o.; daily
Result:

Significantly reduced liver triglyceride levels.
Reduced steatosis scores by 36.8% (P < 0.05) and ballooning scores by 49% (P < 0.05).
Produced a statistically significant improvement in the overall Non-alcoholic Fatty Liver Disease Activity Score (NAS) (P < 0.05).
Showed no significant difference in weight gain compared to vehicle group.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Molecular Weight 526.61
Formula C₂₈H₁₈D₇NO₇S
SMILES

[2H]C([2H])([2H])OC1=CC(OC([2H])([2H])[2H])=CC(/C=C(C(OC)=O)\C2=CC=C(OC3=CC=C(C[C@@]4([2H])C(NC(S4)=O)=O)C=C3)C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pang X, et al. Exploring the therapeutic potential of deuterated PPARγ agonists for NASH. Bioorg Med Chem Lett. 2026;132:130489. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Application
Chemical Information
Purity & Documentation
References

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PPARγ agonist-23

All PPAR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PPARγ agonist-23 Related Classifications

HY-181896S Related Classifications