2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARγ agonist-23

PPARγ agonist-23 (Compound 9) is an orally active PPARγ agonist with an EC50 of 0.32 μM. PPARγ agonist-23 improves hepatic triglyceride levels, reduces scores of steatosis and hepatocellular ballooning, and decreases the total activity score of non-alcoholic steatohepatitis (NASH). PPARγ agonist-23 can be used for the research of non-alcoholic steatohepatitis.

For research use only. We do not sell to patients.

PPARγ agonist-23

PPARγ agonist-23 Chemical Structure

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PPARγ agonist-23 Related Antibodies

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Description

PPARγ agonist-23 (Compound 9) is an orally active PPARγ agonist with an EC50 of 0.32 μM. PPARγ agonist-23 improves hepatic triglyceride levels, reduces scores of steatosis and hepatocellular ballooning, and decreases the total activity score of non-alcoholic steatohepatitis (NASH). PPARγ agonist-23 can be used for the research of non-alcoholic steatohepatitis[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target[1]

PPARγ

0.32 μM (EC50)

In Vitro

PPARγ agonist-23 activates PPARγ in HEK293 cells with an EC50 of 0.32 ± 0.04 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPARγ agonist-23 Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUC0-24 Tmax T1/2
Rat[1] 15 mg/kg p.o. 1693 ± 339 ng/mL 8711 ± 871 ng·h/mL 1.60 ± 0.13 h 2.25 ± 0.45 h
In Vivo

PPARγ agonist-23 (25 mg/kg, p.o., once daily) significantly ameliorates symptoms in mouse models of non-alcoholic steatohepatitis (NASH)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male; NASH induced via high-fat diet and streptozotocin)[1]
Dosage: 25 mg/kg
Administration: p.o.; daily
Result: Significantly reduced liver triglyceride levels.
Reduced steatosis scores by 36.8% (P < 0.05) and ballooning scores by 49% (P < 0.05).
Produced a statistically significant improvement in the overall Non-alcoholic Fatty Liver Disease Activity Score (NAS) (P < 0.05).
Showed no significant difference in weight gain compared to vehicle group.
Molecular Weight

526.61

Formula

C28H18D7NO7S
SMILES

[2H]C([2H])([2H])OC1=CC(OC([2H])([2H])[2H])=CC(/C=C(C(OC)=O)\C2=CC=C(OC3=CC=C(C[C@@]4([2H])C(NC(S4)=O)=O)C=C3)C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPARγ agonist-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist-23PPARγ agonist23PPARγ agonist 23PPARPeroxisome proliferator-activated receptorsliver triglyceridehepatocellular ballooningHEK293 cellsmouse model of NASHnonalcoholic steatohepatitissteatosisperoxisome proliferator-activated receptor gammaTZD derivativesInhibitorinhibitorinhibit

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