country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181896S

Copy Link Print Information

PPARγ agonist-23

PPARγ agonist-23 (Compound 9) is an orally active PPARγ agonist with an EC₅₀ of 0.32 μM. PPARγ agonist-23 improves hepatic triglyceride levels, reduces scores of steatosis and hepatocellular ballooning, and decreases the total activity score of non-alcoholic steatohepatitis (NASH). PPARγ agonist-23 can be used for the research of non-alcoholic steatohepatitis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₈H₁₈D₇NO₇S
분자량:526.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PPARγ agonist-23 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PPARγ

0.32 μM (EC₅₀)

All PPAR Isoforms :

In Vitro

PPARγ agonist-23 activates PPARγ in HEK293 cells with an EC₅₀ of 0.32 ± 0.04 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-24	T_max	T_1/2
Rat^[1]	15 mg/kg	p.o.	1693 ± 339 ng/mL	8711 ± 871 ng·h/mL	1.60 ± 0.13 h	2.25 ± 0.45 h

In Vivo

PPARγ agonist-23 (25 mg/kg, p.o., once daily) significantly ameliorates symptoms in mouse models of non-alcoholic steatohepatitis (NASH)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male; NASH induced via high-fat diet and streptozotocin)^[1]
Dosage:

25 mg/kg
Administration:

p.o.; daily
Result:

Significantly reduced liver triglyceride levels.
Reduced steatosis scores by 36.8% (P < 0.05) and ballooning scores by 49% (P < 0.05).
Produced a statistically significant improvement in the overall Non-alcoholic Fatty Liver Disease Activity Score (NAS) (P < 0.05).
Showed no significant difference in weight gain compared to vehicle group.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

분자량 526.61
화학식 C₂₈H₁₈D₇NO₇S
SMILES

[2H]C([2H])([2H])OC1=CC(OC([2H])([2H])[2H])=CC(/C=C(C(OC)=O)\C2=CC=C(OC3=CC=C(C[C@@]4([2H])C(NC(S4)=O)=O)C=C3)C=C2)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pang X, et al. Exploring the therapeutic potential of deuterated PPARγ agonists for NASH. Bioorg Med Chem Lett. 2026;132:130489. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PPARγ agonist-23

All PPAR Isoforms