RASSF1 Antibody (YA5156)
(Synonyms: RASSF1; RDA32; Ras association domain-containing protein 1)RASSF1 Antibody (YA5156) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RASSF1.
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Host:
Mouse
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-1:2000 |
Product Details
RASSF1 Antibody (YA5156) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RASSF1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 39 kDa;
Purified recombinant human RASSF1 protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RASSF1 is a Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage
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Subcellular Localization
Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Nucleus; Nucleus
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Expression
Tissue_specificity:Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells -
Isoforms & Post-Translational Modification
Q9NS23 has 8 isomers: Q9NS23-1: 39219 Da (predicted); Q9NS23-2: 38814 Da (predicted); Q9NS23-3: 21899 Da (predicted); Q9NS23-4: 31226 Da (predicted); Q9NS23-5: 39265 Da (predicted); Q9NS23-6: 9937 Da (predicted); Q9NS23-7: 16120 Da (predicted); Q9NS23-9: 8656 Da (predicted).
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Subunit
Interacts with MAP1S (PubMed:15205320, PubMed:15753381). Interacts with XPA (PubMed:10888881). Binds to the N-terminal of CDC20 during prometaphase (PubMed:14743218).
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SwissProt ID
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Synonyms
RASSF1; RDA32; Ras association domain-containing protein 1
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