1. Anti-infection
  2. Bacterial
  3. MmpL3-IN-1

MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis.

For research use only. We do not sell to patients.

MmpL3-IN-1 Chemical Structure

MmpL3-IN-1 Chemical Structure

CAS No. : 2290534-93-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis[1].

In Vitro

MmpL3-IN-1 (compound 32) (0.26-64 μg/mL, 2-7days) has potent anti-M. tuberculosis activity with the MIC value of less than 0.016 μg/mL and with almost non-toxic to Vero cells[1].
MmpL3-IN-1 has good microsomal stability and little inhibition of hERG K+ channels with the IC50 value of more than 30 μM[1].
MmpL3-IN-1 (0.0625-1 μg/mL, 16 h) can inhibit TMM transport by targeting MmpL3, thereby affecting the formation of the cell wall of M. tuberculosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0.26-64 μg/mL
Incubation Time: 48 hours
Result: Inhibited cell viability with an IC50 value of 35.3 μg/mL.

Western Blot Analysis[1]

Cell Line: M. tuberculosis H37Rv mc2 6206
Concentration: 0.0625-1 μg/mL
Incubation Time: 16 hours
Result: Resulted in the accumulation of alginate monomycin (TMM) expression and reduced cell wall-bound mycolic acid methyl esters (MAMEs) in a dose-dependent manner.
Reduced synthesis of alginate dimycolate (TDM), together with accumulation of free mycolate at high concentration.
In Vivo

MmpL3-IN-1 (compound 32) (oral gavage, 100 mg/kg, 5 days per week, 30 days) has effective anti-tuberculosis activity in SPF BALB/c female mice with H37Rv[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF BALB/c female mice with H37Rv[1]
Dosage: 100 mg/kg
Administration: Oral gavage; 5 days per week; 30 days
Result: Showed a 2.0 log CFU reduction of H37Rv in lung colony forming units.
Animal Model: BALB/c mouse (female) weighing 20-25 g[1]
Dosage:
Administration: 100 mg/kg p.o. or 10 mg/kg i.v. ; 0-24 hours
Result: b>The pharmacokinetic parameters of MmpL3-IN-1 (compound 32)
Parameter iv, 10 mg/kg po, 100 mg/kg
t1/2(h) 7.37 7.48
Cmax (ng/mL) 5105 211
Tmax(h) 0.03 0.5
AUC0-t(h•ng/mL) 2475 1625
MRT0-t(h•ng/mL) 2.00 8.69
V (mL/kg) 42067 -
CL (mL/h/kg) 3958 -
F% - 6.6
Molecular Weight

357.40

Formula

C20H21F2N3O

CAS No.
SMILES

O=C(C1=CC(C2=CC=C(F)N=C2F)=CN1)NC3C4CC5CC(C4)CC3C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MmpL3-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MmpL3-IN-1
Cat. No.:
HY-150967
Quantity:
MCE Japan Authorized Agent: