1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. KU-32

KU-32 

Cat. No.: HY-108248
Handling Instructions

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.

For research use only. We do not sell to patients.

KU-32 Chemical Structure

KU-32 Chemical Structure

CAS No. : 956498-70-7

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Description

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.

IC50 & Target

Hsp90[1]

In Vitro

Treating human islets with KU-32 for 24 hours shows no toxicity. With a minimum of 2-day exposure, KU-32 improves cellular viability by blocking apoptosis. Functionally, isolated human islets release more glucose-stimulated insulin when preincubate in KU-32[1]. KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro[2].

In Vivo

Diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks do not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice[1].

Molecular Weight

407.41

Formula

C₂₀H₂₅NO₈

CAS No.

956498-70-7

SMILES

CC1=C(O2)C(C=C(NC(C)=O)C2=O)=CC=C1O[[email protected]]3[[email protected]@H]([[email protected]@H]([[email protected]@H](OC)C(C)(C)O3)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Islets are placed into 96-well plates and subjected to a 8-point dose of KU-32 in either low (5 mM) or high (17.5 mM) glucose in DMEM : F12 media and incubated overnight at 37°C and 5% CO2. Twenty-four hours later, alamarBlue is added directly to each well to achieve a final concentration of 10% alamarBlue. Readings on a microplate reader are collected 4, 24, and 48 hours later[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration

Male and female lepr mice are used. At 10 weeks of age, animals are given once per week intraperitoneal injection of 5% Captisol or 20 mg/kg KU-32 in 5% Captisol. At termination of the study, blood from each animal is collected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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KU-32
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HY-108248
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