hCA/VEGFR-2-IN-5
hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC50 values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity.
For research use only. We do not sell to patients.
- Formula: C26H34N4O10S
- Molecular Weight:594.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR-2 0.38 μM (IC50) |
hCA IX 40 nM (IC50) |
hCA XII 3.2 nM (IC50) |
hCA/VEGFR-2-IN-5 in HepG-2 and MCF-7 cells with IC50values of 8.39~16.90 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 594.63
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Formula C26H34N4O10S
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SMILES
O=S(C1=CC=C(N2N=NC(CO[C@H]3[C@@H]([C@H]([C@@H](CO3)OC(C)=O)OC(C)=O)OC(C)=O)=C2)C=C1)(NC4CCCCC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCA/VEGFR-2-IN-5 Related Classifications
HY-163710 Related Classifications
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