OPC 33540
OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies.
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- CAS. Nr.: 189362-27-4
- Formel: C27H39N3O4
- Molecular Weight:469.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PDE3A 0.32 nM (IC50) |
PDE3B 1.5 nM (IC50) |
PDEI 42.9 μM (IC50) |
PDE2 52.3 μM (IC50) |
PDE4 100.8 μM (IC50) |
PDE7 51.3 μM (IC50) |
PDE5 2.5 μM (IC50) |
In Vitro
Chemical Information
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CAS. Nr. 189362-27-4
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Molecular Weight 469.62
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Formel C27H39N3O4
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SMILES
O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CCCCCCC3)[C@H]4[C@H](O)CCCC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
OPC 33540 Related Classifications
HY-112631 Related Classifications
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