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Results for "

anti-tumoral activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (1) 5-HT Receptor (3) Acetyl-CoA Carboxylase (3) Ack1 (1) Acyltransferase (2) ADC Antibody (8) ADC Linker (1) ADC Payload (11) Adenosine Deaminase (2) Adenosine Receptor (7) Adrenergic Receptor (7) Akt (55) Aldose Reductase (2) Aminopeptidase (1) Aminotransferases (Transaminases) (1) AMPK (15) Amylases (1) Amyloid-β (7) Anaplastic lymphoma kinase (ALK) (11) Androgen Receptor (12) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (47) Antibody-Drug Conjugates (ADCs) (12) Antifolate (4) AP-1 (4) Apoptosis (435) Arf Family GTPase (1) Arp2/3 Complex (1) Aryl Hydrocarbon Receptor (2) ASK1 (2) Atg7 (1) Atg8/LC3 (6) ATM/ATR (13) ATP Synthase (1) Aurora Kinase (8) AUTACs (1) Autophagy (99) AUTOTACs (1) Bacterial (97) Bcl-2 Family (36) BCL6 (1) Bcr-Abl (6) Beta-secretase (2) Biochemical Assay Reagents (18) BMI1 (1) BMX Kinase (1) Bombesin Receptor (2) Btk (6) c-Fms (6) c-Kit (6) c-Met/HGFR (16) c-Myc (7) C-type Lectin-like Receptors (CTLRs) (2) Cadherin (1) Calcium Channel (8) CaMK (1) Cannabinoid Receptor (1) Carbonic Anhydrase (9) Carboxypeptidase (1) Carnitine Palmitoyltransferase (CPT) (3) Casein Kinase (1) Caspase (50) Cathepsin (1) CCR (2) CD1 (1) CD19 (1) CD20 (4) CD276/B7-H3 (3) CD3 (2) CD38 (2) CD47 (8) CD73 (5) CDK (41) Ceramidase (1) CETP (1) Checkpoint Kinase (Chk) (9) Chloride Channel (2) Choline Kinase (3) Cholinesterase (ChE) (4) Claudin (1) ClpP (2) CMV (2) COX (26) CTLA-4 (1) Cuproptosis (1) CXCR (9) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (2) Cytochrome P450 (9) Dengue Virus (1) Deubiquitinase (2) DGK (3) Discoidin Domain Receptor (4) Disulfidptosis (1) DNA Alkylator/Crosslinker (9) DNA Methyltransferase (8) DNA Stain (1) DNA/RNA Synthesis (45) DOCK (1) Drug Derivative (17) Drug Intermediate (12) Drug Isomer (1) Drug Metabolite (11) Drug-Linker Conjugates for ADC (17) DYRK (1) E1/E2/E3 Enzyme (10) E3 Ligase Ligand-Linker Conjugates (7) Early 2 Factor (E2F) (1) EBV (3) EGFR (33) Emopamil Binding Protein (1) 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(HCAR) (8) HyT (1) IAP (4) IDE (1) IFNAR (7) IGF-1R (5) iGluR (2) IKK (1) IKZF Family (3) Indoleamine 2,3-Dioxygenase (IDO) (4) Influenza Virus (10) Insecticide (2) Insulin Receptor (2) Integrin (9) Interleukin Related (42) IRE1 (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (39) JAK (22) JNK (22) Keap1-Nrf2 (20) Kinesin (4) Lactate Dehydrogenase (4) LAG-3 (1) LDLR (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (7) LILRB (1) Liposome (2) Lipoxygenase (1) LXR (2) mAChR (3) MAP3K (3) MAP4K (4) MAPKAPK2 (MK2) (2) MDM-2/p53 (25) MEK (6) Melatonin Receptor (1) MELK (2) MetAP (2) Methionine Adenosyltransferase (MAT) (2) METTL3 (2) MHC (2) MicroRNA (2) Microtubule/Tubulin (32) Mitochondrial Metabolism (14) Mitophagy (1) Mitosis (5) Mixed Lineage Kinase (1) MMP (15) Molecular Glues (10) Monoamine Oxidase (10) Monocarboxylate Transporter (1) Mps1 (2) mTOR (32) Mucin (1) Na+/K+ ATPase (5) NAMPT (2) Necroptosis (4) NF-κB (73) NO Synthase (11) NOD-like Receptor (NLR) (9) Notch (2) NTPDase (2) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (53) Opioid Receptor (1) Oxidative Phosphorylation (2) P-glycoprotein (14) P2X Receptor (4) p38 MAPK (23) p62 (6) PAK (2) Parasite (16) PARP (34) PCSK9 (1) PD-1/PD-L1 (29) PDGFR (2) PDHK (1) PDK-1 (2) Peptide-Drug Conjugates (PDCs) (1) PERK (11) PGE synthase (1) Phosphatase (9) Phosphodiesterase (PDE) (8) Phospholipase (2) Phosphoramidites (9) Photosensitizer (1) PI3K (36) Pim (1) PINK1/Parkin (3) PKA (5) PKC (7) Platelet-activating Factor Receptor (PAFR) (2) Polo-like Kinase (PLK) (5) Potassium Channel (5) PPAR (14) Prion Protein (3) Programmed Cell Death 4 (PDCD4) (2) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (3) PROTAC Linkers (2) PROTAC-Linker Conjugates for PAC (1) PROTACs (44) Proteasome (3) Proteolytic Enzyme (1) PTEN (4) Pyroptosis (4) Pyruvate Kinase (3) RAD51 (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (13) RAR/RXR (5) Ras (29) Reactive Oxygen Species (ROS) (76) Reference Standards (133) RET (6) REV-ERB (1) Reverse Transcriptase (5) Ribosomal S6 Kinase (RSK) (3) RIBOTAC (3) RIP kinase (2) ROR (1) ROS Kinase (4) RSV (2) S-adenosylhomocysteine hydrolase (SAHH) (2) S100 Protein (2) SARS-CoV (7) Separase (1) Ser/Thr Protease (6) Serotonin Transporter (5) SF3B1 (1) SHP1 (1) SHP2 (4) Sialyltransferase (1) Sigma Receptor (1) Sirtuin (6) Small Interfering RNA (siRNA) (1) Smo (2) SOD (4) Sodium Channel (1) Somatostatin Receptor (1) SOS1 (2) Src (9) SRPK (1) STAT (50) Stearoyl-CoA Desaturase (SCD) (2) STING (4) Survivin (4) SWI/SNF Complex (1) Syk (1) TAM Receptor (5) Target Protein Ligand-Linker Conjugates (7) Tau Protein (1) TGF-beta/Smad (5) TGF-β Receptor (2) Thrombin (3) Tie (3) Tim3 (6) TNF Receptor (24) TNK1 (2) Toll-like Receptor (TLR) (21) Topoisomerase (26) Transmembrane Glycoprotein (14) Trk Receptor (6) TROP2 (1) TRP Channel (4) TrxR (2) Tyrosinase (4) VDAC (1) VEGFR (24) Virus Protease (6) VISTA (3) WDR5 (2) Wee1 (1) Wnt (15) Xanthine Oxidase (1) YAP (4) Zinc Finger Protein (1) α-synuclein (4) β-catenin (8)
By Research Areas:	Cancer (1320) Cardiovascular Disease (57) Endocrinology (16) Infection (177) Inflammation/Immunology (284) Metabolic Disease (78) Neurological Disease (116)
Click Chemistry:	ADC Synthesis (1) DBCO (1) PROTAC Synthesis (1) Azide (6) Alkynes (4)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (38) Aptamers (1) Cationic Lipids (1) Cytosine (9) Phosphoramidites (9) Antisense Oligonucleotides (2) Cytidine (37)

1394

Inhibitors & Agonists

Screening-Bibliotheken

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

103

Inhibitory Antibodies

358

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B0350A

Sodium butyrate 20+ Cited Publications Butanoic acid sodium; Butyric acid sodium	HDAC Autophagy Apoptosis Endogenous Metabolite	Cancer
Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity .

HY-N0184

Glycyrrhizic acid Maximum Cited Publications 59 Publications Verification Glycyrrhizin	Virus Protease	Metabolic Disease Cancer
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

HY-N0156

Oleanolic acid 20+ Cited Publications Oleanic acid; Caryophyllin	MAP3K Autophagy Endogenous Metabolite HIV	Cancer
Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

HY-15433

Quisinostat 15+ Cited Publications JNJ-26481585	HDAC Autophagy	Inflammation/Immunology Cancer
Quisinostat (JNJ-26481585) is a potent and orally active pan-HDAC inhibitor (HDACi), with IC₅₀ values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity . Quisinostat can induce autophagy in neuroblastoma cells .

HY-N0400

Wogonin 20+ Cited Publications	CDK Wnt Autophagy Apoptosis	Inflammation/Immunology Cancer
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.

HY-10249A

AKT Kinase Inhibitor 15+ Cited Publications	Akt	Cancer
AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity .

HY-W013032

Oxamic acid 55+ Cited Publications Oxamidic acid	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-N0462

Corilagin 5+ Cited Publications NP-004255	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy	Infection Inflammation/Immunology Cancer
Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-144875

Rogocekib CTX-712	CDK	Cancer
Rogocekib is an orally effective CLK 2 inhibitor, with an IC₅₀ of 1.4 nM, showing anti-tumor activity .

HY-120350

BI-1347 5+ Cited Publications	CDK	Cancer
BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC₅₀=1.1 nM). BI-1347 shows anti-tumoral activity .

HY-108431

MN58b 1 Publications Verification	Apoptosis	Cancer
MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity .

HY-P1009

Z-YVAD-FMK Maximum Cited Publications 22 Publications Verification	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-15721

FH535 15+ Cited Publications	PPAR Wnt β-catenin	Cancer
FH535 is an inhibitor of Wnt/β-catenin and PPAR with anti-tumor activities .

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-B1436

Nifuroxazide 4 Publications Verification	STAT Bacterial Antibiotic	Infection Cancer
Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity. Nifuroxazide is an orally active nitrofuran antibiotic.

HY-101144

RSM-932A TCD-717	Choline Kinase	Cancer
RSM-932A (TCD-717) is a specific ChoKα inhibitor with IC₅₀s of 1 and 33 μM for human recombinant ChoKα and ChoKβ enzymes, respectively. RSM-932A acts as the “first in humans” compound targeting ChoKα. RSM-932A is potent in vitro anti-proliferative and in vivo anti-tumoral activity against human xenografts in mice, showing high efficacy with low toxicity profiles .

HY-16496

Thiarabine OSI-7836	DNA/RNA Synthesis	Inflammation/Immunology Cancer
Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.

HY-151590

DKFZ-748	HDAC	Cancer
DKFZ-748 is a selective HDAC10 inhibitor (pIC₅₀=7.66), and shows anti-tumor activity .

HY-A0128A

Buclizine dihydrochloride	Histamine Receptor	Inflammation/Immunology Cancer
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity .

HY-126330

SS-208 AVS100	HDAC	Cancer
SS-208 is a selective HDAC6 inhibitor, with an IC₅₀ of 12 nM. SS-208 possesses anti-tumor activity in melanoma .

HY-16509

UNBS5162 5+ Cited Publications	CXCR Autophagy	Endocrinology Cancer
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

HY-10247

BRAF inhibitor 1 Publications Verification	Raf	Cancer
BRAF inhibitor (Compound P-0850) is a B-Raf inhibitor with anti-tumor activity .

HY-N6075

Specneuzhenide Nuezhenide	Others	Cancer
Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity .

HY-111213

PRMT5-IN-20	Histone Methyltransferase	Cancer
PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity .

HY-W007466

Cyclohexane-1,3-dione 1 Publications Verification	Drug Intermediate	Cancer
Cyclohexane-1,3-dione is a drug intermediate, and its derivatives can exhibit significant tyrosine kinase inhibitory activity and anti-tumor activity .

HY-N8207

Gypenoside LI 1 Publications Verification	Apoptosis MicroRNA	Cancer
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-N6988

Cimigenol 1 Publications Verification	Others	Cancer
Cimigenol is an active compound isolated from Cimicifuga, with potent anti-tumor activity .

HY-113450

10Z-Nonadecenoic acid	Endogenous Metabolite	Metabolic Disease Cancer
10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.

HY-14947

Balamapimod MKI 833	MEK	Cancer
Balamapimod (MKI 833) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity.

HY-176809

Parent CDN	STING	Cancer
Parent CDN is a cyclic dinucleotide and a STING agonist. Parent CDN exhibits anti-tumor activity .

HY-N8091

Lehmannine	Bacterial	Infection Cancer
Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities .

HY-N2604

Loureirin C	Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Loureirin C has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities .

HY-128763

HDAC-IN-4	HDAC	Cancer
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC₅₀s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity .

HY-130326

RAPTA-C Ru(η6-p-cymene)Cl2(pta)	Apoptosis Caspase	Cardiovascular Disease Cancer
RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model .

HY-112243A

Cimpuciclib tosylate	CDK	Inflammation/Immunology Cancer
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC₅₀: 0.49 nM) that has anti-tumor activity .

HY-174811

PROTAC BRD4 Degrader-33	PROTACs Epigenetic Reader Domain PD-1/PD-L1	Inflammation/Immunology Cancer
PROTAC BRD4 Degrader-33 is an enzyme activated clickable BRD4 PROTAC degrader with favorable tumor microenvironment-response. PROTAC BRD4 Degrader-33 has superior tumor tissue penetration capabilities and efficiently inhibits PD-L1 protein expression. PROTAC BRD4 Degrader-33 shows potent anti-tumoral immunomodulation activity in 4T1 tumor-bearing mice model . Pink: BRD4 ligand (HY-174812); Blue: CRBN ligase ligand (HY-10984); Black: linker

HY-118276

Lithocholenic acid	Drug Derivative	Cancer
Lithocholenic acid, a derivative of Lithocholic acid, possesses anti-tumor activity .

HY-U00337

Datelliptium chloride	DNA/RNA Synthesis	Cancer
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.

HY-N9390

Wilforlide B	Others	Cancer
Wilforlide B, a natural norditerpenoid, possesses anti-tumor activity in human cancer cells .

HY-N1550

Przewalskin Norsalvioxide	Others	Cancer
Przewalskin (Norsalvioxide) is a natural product found in Salvia yunnanensis. Przewalskin shows anti-tumor activity .

HY-N10602

Caryatin	Others	Cancer
Caryatin is a natural product found in Rhododendron simiarum, and Aeonium decorum. Caryatin shows anti-tumor activity .

HY-13727

Pixantrone free base BBR 2778 free base	Topoisomerase	Cancer
Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-15433B

Quisinostat hydrochloride JNJ26481585 hydrochloride	HDAC Autophagy	Cancer
Quisinostat (JNJ-26481585) hydrochloride is a potent and orally active pan-HDAC inhibitor (HDACi), with IC₅₀ values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat hydrochloride has a broad spectrum antitumoral activity. Quisinostat hydrochloride can induce autophagy in neuroblastoma cells .

HY-B0994

Cyanoacetohydrazide Cyanoacetic hydrazide; 2-Cyanoacetohydrazide	Drug Intermediate	Infection
Cyanoacetohydrazide is a pharmaceutical intermediate. Cyanoacetohydrazide can be used to synthesize acylhydrazide hydrazone derivatives with antibacterial or anti-tumor activity .

HY-P10947

MACTIDE-V	Epigenetic Reader Domain YAP	Cancer
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin (HY-B0146) to CD206 ⁺ tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models .

HY-N10402

Norbatzelladine L	Fungal Bacterial Parasite	Infection Cancer
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N11479

Vallesiachotamine	Apoptosis Necroptosis	Cancer
Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity .

HY-N13259

Fluopsin C	Antibiotic Bacterial	Infection Cancer
Fluopsin C is a copper-containing antibiotic with strong anti-Gram-positive and negative bacteria activity and anti-tumor activity .

HY-N4255

Resibufagin	Others	Cancer
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities .

HY-N8131

Pangelin	Bacterial	Infection Cancer
Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-B0350A

Sodium butyrate 20+ Cited Publications Butanoic acid sodium; Butyric acid sodium	Classification of Application Fields Disease Research Fields Cancer	HDAC Autophagy Apoptosis Endogenous Metabolite
Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity .

HY-N0184

Glycyrrhizic acid Maximum Cited Publications 59 Publications Verification Glycyrrhizin	Triterpenes Classification of Application Fields Leguminosae Terpenoids Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Sweeteners Source Classification Food Research	Virus Protease
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

HY-N0156

Oleanolic acid 20+ Cited Publications Oleanic acid; Caryophyllin	Triterpenes Structural Classification other families Classification of Application Fields Anti-aging Terpenoids Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	MAP3K Autophagy Endogenous Metabolite HIV
Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

HY-N0400

Wogonin 20+ Cited Publications	Flavonoids Classification of Application Fields Flavones Labiatae Phenols Polyphenols Plants Medicago truncatula Gaertn. Inflammation/Immunology Disease Research Fields Source Classification	CDK Wnt Autophagy Apoptosis
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.

HY-N0669

Stevioside 4 Publications Verification	Trifolium hybridum L. Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Disease Research Fields Sweeteners Source Classification Cancer Food Research	Apoptosis
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-N0452

Hyperoside 20+ Cited Publications Quercetin 3-O-galactoside; Quercetin 3-O-β-D-galactopyranoside	Flavonols Flavonoids Classification of Application Fields Guttiferae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Hypericum monogynum L. Source Classification	Influenza Virus Fungal NF-κB Apoptosis
Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis .

HY-W013032

Oxamic acid 55+ Cited Publications Oxamidic acid	Microorganisms Source Classification	Lactate Dehydrogenase Apoptosis
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis .

HY-N0351

p-Coumaric acid 3 Publications Verification trans-4-Hydroxycinnamic acid	Monophenols Microorganisms other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Bacterial Apoptosis
p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities .

HY-N0462

Corilagin 5+ Cited Publications NP-004255	Phyllanthus urinaria Linn. Infection Structural Classification Classification of Application Fields Phenols Polyphenols Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-N6653

Lentinan 5+ Cited Publications	Polysaccharides Agaricaceae Classification of Application Fields Lentinus edodes (Berk. ) Sing Plants Disease Research Fields Saccharides Source Classification Cancer	JAK Keap1-Nrf2 Apoptosis
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering ^[1][4].

HY-125850

Berberrubine chloride 2 Publications Verification	Alkaloids Phellodendron amurense Rupr. Monophenols Classification of Application Fields Rutaceae Phenols Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite HIV Interleukin Related
Berberrubine chloride is an orally active metabolite of berberine. Berberrubine chloride alleviates mucosal lesions and inflammation in mouse colitis models. Berberrubine chloride has anti-inflammatory, anti-tumor, and antiviral activities .

HY-N0205

Pulchinenoside C 5 Publications Verification Anemoside B4	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Source Classification Cancer	Others
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

HY-N0011

Baohuoside I 15+ Cited Publications Icariin-II; Icariside-II	Flavonols Classification of Application Fields Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Epimedium koreanum Nakai Phenols Polyphenols Berberidaceae Inflammation/Immunology Disease Research Fields Endocrinology Source Classification Cancer	CXCR Apoptosis
Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.

HY-N2959

Brevilin A 5 Publications Verification	Centipeda minima (L.) A. Braun & Asch. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Source Classification Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-18981

Decursin 2 Publications Verification (+)-Decursin	Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	PKC Apoptosis CXCR
Decursin ((+)-Decursin) is a potent *anti-tumor* agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities .

HY-N0344

Farrerol 5+ Cited Publications (-)-Farrerol	Structural Classification Rhododendron dauricum Linn. Neurological Disease Classification of Application Fields Plants Flavonoids Flavonones Phenols Polyphenols Ericaceae Inflammation/Immunology Disease Research Fields Source Classification	Others
Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects .

HY-N1451

Betulonic acid 5 Publications Verification Betunolic acid; Liquidambaric acid; (+)-Betulonic acid	Infection Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Parasite HSV
Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities .

HY-N1200

Stigmasterol glucoside	other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	5 alpha Reductase
Stigmasterol glucoside is a sterol compound and a 5α-reductase inhibitor with an IC₅₀ value of 27.2 µM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities .

HY-N0222

Avicularin 5+ Cited Publications	Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields Source Classification	COX NF-κB PPAR ERK GLUT Apoptosis
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .

HY-N4116

Xanthyletin	Infection other families Classification of Application Fields Coumarins Phenylpropanoids Stauranthus perforatus Plants Disease Research Fields Source Classification Cancer	Fungal
Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants .

HY-N4058

Helichrysetin	Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-N6004

(Rac)-Shikonin 1 Publications Verification Shikalkin	Quinones Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	Others
(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer agent resistance by induction of a necroptotic death .

HY-117260

Coformycin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Adenosine Deaminase Bacterial Antibiotic
Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity .

HY-B1461

Deoxyarbutin	Natürliche Produkte Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification	Tyrosinase Apoptosis
Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-N8432

Dipyrithione	Infection Structural Classification Natürliche Produkte Classification of Application Fields Plants Annonaceae Marsypopetalum littorale (Bl.) B. Xue & R. M. K. Inflammation/Immunology Disease Research Fields Source Classification Cancer	Environmental Pollutants Bacterial Apoptosis Fungal
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis .

HY-N6075

Specneuzhenide Nuezhenide	Monophenols other families Iridoids Classification of Application Fields Terpenoids Phenols Plants Disease Research Fields Cancer Source Classification	Others
Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity .

HY-N8207

Gypenoside LI 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification Cancer	Apoptosis MicroRNA
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-W005130

2,4,6-Trihydroxybenzaldehyde	Monophenols Animals Phenols	NF-κB
2,4,6-Trihydroxybenzaldehyde is an orally active NF- B inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity .

HY-N0184R

Glycyrrhizic acid (Standard) Glycyrrhizin (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Virus Protease
Glycyrrhizic acid (Standard) is the analytical standard of Glycyrrhizic acid. This product is intended for research and analytical applications. Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

HY-N6988

Cimigenol 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Plants Cimicifuga foetida Linn. Disease Research Fields Cancer Source Classification	Others
Cimigenol is an active compound isolated from Cimicifuga, with potent anti-tumor activity .

HY-113450

10Z-Nonadecenoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.

HY-N8091

Lehmannine	Infection Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora alopecuroides L Plants Disease Research Fields Source Classification	Bacterial
Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities .

HY-N2604

Loureirin C	Infection Natürliche Produkte other families Neurological Disease Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Loureirin C has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities .

HY-N0462R

Corilagin (Standard) NP-004255 (Standard)	Phyllanthus urinaria Linn. Structural Classification Phenols Polyphenols Euphorbiaceae Plants Source Classification	Toll-like Receptor (TLR) Reference Standards Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin (Standard) is the analytical standard of Corilagin. This product is intended for research and analytical applications. Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-N0156R

Oleanolic acid (Standard) Oleanic acid (Standard); Caryophyllin (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Endogenous metabolite Source Classification	MAP3K Reference Standards Autophagy Endogenous Metabolite HIV
Oleanolic acid (Standard) is the analytical standard of Oleanolic acid. This product is intended for research and analytical applications. Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

HY-N6990

Anhydrosecoisolariciresinol	other families Classification of Application Fields Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-N1238

β-Sitostenone Δ4-Sitosterol-3-one; β-Rosasterol oxide	Sphagnum palustre L. Structural Classification Classification of Application Fields Whitening Agent Sphagnaceae Metabolic Disease Cosmetic Research Plants Disease Research Fields Steroids Source Classification	Tyrosinase Endogenous Metabolite
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities .

HY-N16416

Dregamine	Apocynaceae Alkaloids Plants Tabernaemontana elegans Stapf Indole Alkaloids Source Classification	Apoptosis
Dregamine is a monoterpene indole organism that can be isolated from methanol extracts of bamboo and rattan roots and can induce apoptosis. Dregamine has anti-tumor activity .

HY-N2432

Paederoside 1 Publications Verification	Infection Iridoids Classification of Application Fields Terpenoids Paederia scandens (Lour.) Merr. Rubiaceae Plants Disease Research Fields Source Classification	EBV HBV
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation .

HY-122493

Illudin M	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Disease Research Fields Cancer Source Classification	DNA Alkylator/Crosslinker Apoptosis
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-N9390

Wilforlide B	Triterpenes Classification of Application Fields Terpenoids Celastraceae Plants Euonymus echinatus Wall. Disease Research Fields Source Classification Cancer	Others
Wilforlide B, a natural norditerpenoid, possesses anti-tumor activity in human cancer cells .

HY-N1550

Przewalskin Norsalvioxide	Terpenoids Labiatae Diterpenoids Plants Indigofera kirilowii Maxim. ex Palib	Others
Przewalskin (Norsalvioxide) is a natural product found in Salvia yunnanensis. Przewalskin shows anti-tumor activity .

HY-N10602

Caryatin	Flavonoids Leguminosae Acacia catechu (Linn. f.) Willd. Plants Isoflavones	Others
Caryatin is a natural product found in Rhododendron simiarum, and Aeonium decorum. Caryatin shows anti-tumor activity .

HY-135533

Chromomycin A2 Aburamycin A	Structural Classification Natürliche Produkte Microorganisms Source Classification	Autophagy
Chromomycin A2 (Aburamycin A) has cytotoxicity and induces autophagy. Chromomycin A2 has anti-tumor activity and can be used in cancer research .

HY-N2490

Dehydrotrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Inflammation/Immunology Disease Research Fields Source Classification	Caspase Apoptosis
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

HY-N10402

Norbatzelladine L	Alkaloids Microorganisms Source Classification	Fungal Bacterial Parasite
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N11479

Vallesiachotamine	Apocynaceae Alkaloids Melodinus suaveolens (Hance) Champ. ex Benth. Plants Indole Alkaloids Source Classification	Apoptosis Necroptosis
Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity .

HY-N13259

Fluopsin C	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Fluopsin C is a copper-containing antibiotic with strong anti-Gram-positive and negative bacteria activity and anti-tumor activity .

HY-N4255

Resibufagin	Structural Classification Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Others
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities .

HY-N8131

Pangelin	Infection other families Classification of Application Fields Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Bacterial
Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .

Art. -Nr.	Produktname	Chemical Structure

HY-N0368S

Linalool-d3 1 Publications Verification
Linalool-d₃ is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC₅₀s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator .

HY-B2227BS

Lactic acid-d4 sodium (60% w/w in water)

Lactic acid-d₄ (DL-Lactic acid-d₄) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B2227BS1

Lactic acid-d3 sodium (60% w/w in water)

Lactic acid-d₃ (DL-Lactic acid-d₃) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-W015490S

1,4-Naphthoquinone-d6

1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC₅₀ ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .

HY-N0156S

Oleanolic acid-d3
Oleanolic acid-d₃ is the deuterium labeled Oleanolic Acid . Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities .

HY-101566S

Elimusertib-d3
Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity .

HY-16106S

Talazoparib-13C,d4
Talazoparib- ¹³C,d4 is ¹³C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

HY-142283AS

Dosimertinib-d5 mesylate
Dosimertinib-d₅ (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d₅ (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₅ (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d₅ (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC) .

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-19542S1

C6 Ceramide-d11
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-142283

Dosimertinib
Dosimertinib-d₃-d₃ is a potent and orally active EGFR inhibitor. Dosimertinib-d₃-d₃ decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₃-d₃ shows antiproliferative and anti-tumor activity. Dosimertinib-d₃-d₃ has the potential for the research of non-small-cell lung cancer (NSCLC) .

HY-15149S2

Romidepsin-d7

Romidepsin-d₇ (FK 228-d₇) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-17509S

Deracoxib-d3

Deracoxib-d₃ (SC 046-d₃; SC 59046-d₃) is the deuterium labeled Deracoxib (HY-17509). Deracoxib, an orally active COX-2 inhibitor, is a veterinary nonsteroidal anti-inflammatory agent used exclusively in dogs. Deracoxib inhibits the COX-2 enzyme to reduce the production of prostaglandins, effectively controlling pain and inflammation after canine soft tissue surgery. Deracoxib reduces the inhibition of COX-1 and lowers the risk of gastrointestinal side effects. Deracoxib induces tumor cell cycle arrest and apoptosis, and shows anti-tumor activity in canine osteosarcoma, breast tumors and bladder transitional cell carcinomas.

HY-N0168AS1

(Rac)-Hesperetin-13C,d3

(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-N0007S

Bisdemethoxycurcumin-d8

Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .

HY-W653896

Alternariol-d2

Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-B1436S

Nifuroxazide-d4
Nifuroxazide-d₄ is the deuterium labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.

HY-B1436S1

Nifuroxazide-13C6
Nifuroxazide- ¹³C₆ is the ¹³C₆ labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109AS

Dorzolamide-d3 hydrochloride
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109AS1

Dorzolamide-d5hydrochloride
Dorzolamide-d₅(hydrochloride) (L671152 hydrochloride-d₅) is deuterium labeled Dorzolamide (hydrochloride). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-170905S

MAT2A-IN-22
MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC₅₀ of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects .

HY-B1637S

Ditiocarb-d10 sodium

Ditiocarb-d₁₀ sodium (Sodium diethyldithiocarbamate-d₁₀) is the deuterium labeled Ditiocarb sodium (HY-B1637). Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .

HY-B0091S

Adapalene-d3
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-W744741

Lupeol-d3
Lupeol-d₃ is the deuterium labeled Lupeol (HY-N0790). Lupeol is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor?(AR)?inhibitor and can be used for?cancer?research, especially prostate?cancer?of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-W759435

Niraparib-d5
Niraparib-d₅ (MK-4827-d₅) is the deuterium labeled Niraparib (HY-10619). Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC₅₀s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity .

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-168968S

ZJY-54
ZJY-54 is an orally active dual-target inhibitor of EGFR/LSD1, with IC₅₀ values of 3.8 nM and 0.6 μM, respectively. ZJY-54 can inhibit the proliferation of non-small cell lung cancer cells, induce the accumulation of H3K4me2 and H3K9me2, and inhibit the phosphorylation of the EGFR signaling pathway. ZJY-54 has anti-tumor activity .

HY-W769991

Lactate sodium-13C2

Lactic acid- ¹³C₂ (DL-Lactic acid- ¹³C₂) sodium is the ¹³C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative .

HY-15728S

Radotinib-d6

Radotinib-d₆ is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

HY-18174S

Prexasertib-d4

Prexasertib-d₄ (LY2606368-d₄) is the deuterium labeled Prexasertib (HY-18174). Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity .

HY-111124

Paroxetine-d2

Paroxetine-d₂ (CTP 347) is a deuterium labeled Paroxetine (HY-122272). Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-10201S4

Sorafenib-d3 tosylate

Sorafenib-d₃ (Donafenib-d₃) tosylate is the deuterium labeled Sorafenib (HY-10201). Sorafenib is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib-d3tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib-d3tosylate induces autophagy and apoptosis. Sorafenib-d3tosylate has anti-tumor activity. Sorafenib is a ferroptosis activator .

HY-W703540

Deracoxib-d4

Deracoxib-d₄ (SC 046-d₄; SC 59046--d₄) is deuterium labeled Deracoxib (HY-17509). Deracoxib, an orally active COX-2 inhibitor, is a veterinary nonsteroidal anti-inflammatory agent used exclusively in dogs. Deracoxib inhibits the COX-2 enzyme to reduce the production of prostaglandins, effectively controlling pain and inflammation after canine soft tissue surgery. Deracoxib reduces the inhibition of COX-1 and lowers the risk of gastrointestinal side effects. Deracoxib induces tumor cell cycle arrest and apoptosis, and shows anti-tumor activity in canine osteosarcoma, breast tumors and bladder transitional cell carcinomas.

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-N0168AS

(Rac)-Hesperetin-d3

(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-W723781

Sodium butyrate-d3
Sodium butyrate-d₃ (Butanoic acid-d₃ sodium) is the deuterium labeled Sodium butyrate (HY-B0350A). Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity .

HY-W723834

Sodium butyrate-d5
Sodium butyrate-d₅ (Butanoic acid-d₅ sodium) is the deuterium labeled Sodium butyrate (HY-B0350A). Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity .

HY-18981S

Decursin-d6

Decursin-d₆ ((+)-Decursin-d₆) is the deuterium labeled Decursin (HY-18981). Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities .

HY-W752012

Adapalene-13C6

Adapalene- ¹³C₆ (CD271- ¹³C₆) is the ¹³C-labeled Adapalene (HY-B0091). Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-178398S

Nonadecanoic acid-d3

Nonadecanoic acid-d₃ is the deuterium labeled Nonadecanoic acid (HY-W004261). Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production .

HY-13062AS

Daunorubicin-13C,d3 TFA

Daunorubicin- ¹³C,d₃ TFA (Daunomycin- ¹³C,d₃ TFA) is the deuterium and ¹³C-labeled Daunorubicin TFA. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-W766368

C6 Ceramide-13C2,d2

C6 Ceramide- ¹³C₂,d₂ (C6-Cer- ¹³C₂,d₂) is the deuterium labeled and ¹³C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B0350AG

Sodium butyrate Butanoic acid sodium; Butyric acid sodium	HDAC Autophagy Apoptosis Endogenous Metabolite	Cancer
Sodium butyrate (GMP) refers to Sodium butyrate (HY-B0350A) of GMP grade. Small molecules of GMP grade can be used as adjuvants in cell therapy. Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity .

HY-15149G

Romidepsin FK 228; FR 901228; NSC 630176	HDAC Apoptosis	Cancer
Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

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