2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. LP23

LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg).

For research use only. We do not sell to patients.

LP23

LP23 Chemical Structure

CAS No. : 3008239-25-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

LP23 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg)[1].

IC50 & Target

IC50: 16.7 nM (PD-L1)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
8.9 μM
Compound: LP23
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37674362]
B16-F10 IC50
> 10 μM
Compound: LP23
Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37674362]
HepG2 IC50
4.32 μM
Compound: LP23
Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antitumor immunity against IFNgamma-stimulated human HepG2 cells expressing human PD-L1 co-cultured with PHA-stimulated human Jurkat T cells expressing human PD-1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37674362]
MCF7 IC50
7.9 μM
Compound: LP23
Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37674362]
Molecular Weight

505.59

Formula

C27H27N3O5S
CAS No.
SMILES

O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LP23 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP233008239-25-3LP 23LP-23PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LP23
Cat. No.:
HY-156085
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.