3008239-25-3
3008239-25-3
Chemical Structure
LP23
- CAS No.: 3008239-25-3
- Formula:C27H27N3O5S
- Molecular Weight:505.59
InChIKey: AAJMOHIHVOUUDE-QHCPKHFHSA-N
SMILES: O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
Biological Activity: LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LP23 | 99.9% | LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg). | ||||||||||||||||||||
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References
Keywords
