2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BI-4732

BI-4732 a potent inhibitor EGFR-activating (E19del and L858R) and T790M mutations, with high blood-brian barrier penetration, targeting a broad range of EGFR mutations, including C797S. BI-4732 has anti-tumor activity.

For research use only. We do not sell to patients.

BI-4732 Chemical Structure

BI-4732 Chemical Structure

CAS No. : 2769715-68-4

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Description

BI-4732 a potent inhibitor EGFR-activating (E19del and L858R) and T790M mutations, with high blood-brian barrier penetration, targeting a broad range of EGFR mutations, including C797S. BI-4732 has anti-tumor activity[1].

Molecular Weight

592.69

Formula

C32H36N10O2
CAS No.
SMILES

CC1=C(C=NN2C3=NC(N4C[C@@H]5OC[C@H]4C5)=C6C(N(C)C(N7C[C@@H](CCC8)N8CC7)=N6)=C3)C2=CC(C9=C(OC)C=CN=C9)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BI-4732 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-47322769715-68-4BI4732BI 4732EGFREpidermal growth factor receptorErbB-1HER1osimertinibantitumor blood-brain barrierInhibitorinhibitorinhibit

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