2. Apoptosis
  3. Bcl-2 Family
  4. SMBA1

SMBA1 is a potent Bax agonist with a Ki value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer.

For research use only. We do not sell to patients.

SMBA1 Chemical Structure

SMBA1 Chemical Structure

CAS No. : 906440-37-7

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SMBA1 Related Antibodies

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Description

SMBA1 is a potent Bax agonist with a Ki value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer[1].

IC50 & Target[1]

Bax

43.3 nM (Ki)

In Vitro

SMBA1 induces conformational changes in Bax by blocking S184 phosphorylation, facilitating Bax insertion into mitochondrial membranes and forming Bax oligomers shows Bax agonist activity[1].
. SMBA1 (0, 0.1, 1, 5, 10 µM; 24 h) enhances the Bax expression in a dose-dependent manner in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMBA1 Related Antibodies

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 0.1, 1, 5, 10 µM
Incubation Time: 24 h
Result: Increased the Bax expression in a dose-dependent manner
In Vivo

SMBA1 (2, 10, 40, 60 mg/kg; i.p.; once daily for 10 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male Nu/Nu mice (A549 lung cancer xenografts)[1]
Dosage: 2, 10, 40, 60 mg/kg
Administration: I.p.; once daily for 10 days
Result: Supressed the tumor volume and increased levels of active caspase 3.
Molecular Weight

315.32

Formula

C20H13NO3
CAS No.
SMILES

OC1=CC=CC=C1/C=C2C3=C(C4=C\2C=CC=C4)C=CC([N+]([O-])=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMBA1 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMBA1906440-37-7SMBA 1SMBA-1Bcl-2 FamilyBaxanti-tumorlung cancerA549 cellsInhibitorinhibitorinhibit

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