ROS kinases-IN-1
Based on 1 Customer Validation
ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 98.30%
- CAS No.: 370096-57-4
- Formula: C20H16N4O
- Molecular Weight:328.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Covalent Screening Library
HY-L036
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Membrane Protein-targeted Compound Library
HY-L149
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Covalent Screening Library Plus
HY-L036P
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
IC50: 1.22 μM (ROS kinase)[1]
ROS kinases-IN-1 (1-100 μM; 1 d) inhibits the growth of cervical cancer cell and glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, U138, U87, LN18, and U118 cells
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Concentration:1, 10, and 100 μM
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Incubation Time:one day
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Result:Showed EC50s for HeLa, U138, U87, LN18, and U118 cells of 20, 8, 8, 12, and 7 μM, respectively.
Chemical Information
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CAS No. 370096-57-4
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Appearance Solid
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Molecular Weight 328.37
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Formula C20H16N4O
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Color Light yellow to yellow
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SMILES
O=C1NN=C(C)/C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20.83 mg/mL (63.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0453 mL | 15.2267 mL | 30.4535 mL | 76.1336 mL |
| 5 mM | 0.6091 mL | 3.0453 mL | 6.0907 mL | 15.2267 mL | |
| 10 mM | 0.3045 mL | 1.5227 mL | 3.0453 mL | 7.6134 mL | |
| 15 mM | 0.2030 mL | 1.0151 mL | 2.0302 mL | 5.0756 mL | |
| 20 mM | 0.1523 mL | 0.7613 mL | 1.5227 mL | 3.8067 mL | |
| 25 mM | 0.1218 mL | 0.6091 mL | 1.2181 mL | 3.0453 mL | |
| 30 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5378 mL | |
| 40 mM | 0.0761 mL | 0.3807 mL | 0.7613 mL | 1.9033 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 60 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL |
ROS kinases-IN-1 Related Classifications
HY-148228 Related Classifications
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