1. Apoptosis
  2. Apoptosis
  3. 4-(Dodecylamino)phenol

4-(Dodecylamino)phenol  (Synonyms: p-DDAP; p-Dodecylaminophenol)

Cat. No.: HY-131724
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4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer.

For research use only. We do not sell to patients.

4-(Dodecylamino)phenol Chemical Structure

4-(Dodecylamino)phenol Chemical Structure

CAS No. : 25848-37-7

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Description

4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer[1][2].

In Vitro

4-(Dodecylamino)phenol (p-DDAP) (0-10 μM; 72 h) induces growth arrest in NB-39-nu cells[1].
p-DDAP (0.1, 0.2, 0.4, 10 μM; ) arrestes the cell cycle in the G0/G1 phase in dose-dependent manner[1].
p-DDAP (0.2 μM; 48 h) induces apoptotosis without differentiation[1].
p-DDAP (0.2, 0.4, 1 μM; 24 h, 72 h) induces apoptotic cell death through bcl-2 down-regulation and caspases activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: NB-39-nu cells
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Showed potent growth inhibitory effects against NB-39-nu cells.

Cell Cycle Analysis[1]

Cell Line: NB-39-nu cells
Concentration: 0.1, 0.2, 0.4, 10 μM
Incubation Time: 24 h
Result: Induced G0/G1-phase arrest in NB-39-nucells.

Apoptosis Analysis[1]

Cell Line: NB-39-nu cells
Concentration: 0.2 μM
Incubation Time: 48 h
Result: Induced G0/G1-phase arrest, displayed morphological apoptotic features, including aggregation and nuclear fragmentation in NB-39-nu cells.
In Vivo

4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen-free athymic BALB/c nu/nu nude mice (6 weeks of age, male)[2]
Dosage: 10, 15, 40 mg/kg
Administration: i.v., daily, for 2 weeks or i.p., single
Result: Suppressed tumor growth in PC-3-implanted mice in vivo.
Molecular Weight

277.44

Formula

C18H31NO

CAS No.
SMILES

OC1=CC=C(NCCCCCCCCCCCC)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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4-(Dodecylamino)phenol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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