Cat. No.: HY-N0330

Momordin Ic

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity.

For research use only. We do not sell to patients.

Purity: 99.78%
CAS No.: 96990-18-0
Formula: C₄₁H₆₄O₁₃
Molecular Weight:764.94

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Momordin Ic Chemical Structure

CAS No.: 96990-18-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

In Vitro

Momordin Ic (0-20 μM, 48 h) relies on cholesterol and ganglioside GM1 to enhance the toxicity of recombinant protein MAP30 in breast cancer cells^[2].
Momordin Ic (10 μM, 24 h) induces colon cancer cell cycle arrest and apoptosis by inhibiting the SENP1/c-MYC signaling pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]^[2].

Cell Line:

HepG2 cell; MDA-MB-231, MCF-7, HepG2, H460, A549, HeLa cells
Concentration:

0-20 μM
Incubation Time:

4 h; 48 h
Result:

Inhibited growth in HepG2 cells; Enhanced the cytotoxicity of MAP30 to breast cancer cells.

Apoptosis Analysis^[1].

Cell Line:

HepG2 cell
Concentration:

0-15 μM
Incubation Time:

4 h
Result:

Reduced the protein levels of caspase-3 and Bcl-2, and increased the protein levels of cytochrome c and Bax in the cytoplasmicsol.

Western Blot Analysis^[3].

Cell Line:

HCT-8 cell, HCT-116 cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Reduced the level of c-Myc protein.

In Vivo

Momordin Ic (12.5, 25, 50 mg/kg, p.o.) accelerates gastrointestinal transport and inhibits gastric emptying in mice by stimulating the synthesis of serotonin (5-HT)^[4].
Momordin Ic (10 mg/kg, p.o.) can inhibit ethanol induced gastric mucosal lesions in rats^[5].
Momordin Ic (30 mg/kg, once a day for 14 days, p.o.) can reduce CCl₄-induced hepatotoxicity in rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ddY mice^[4].
Dosage:

12.5, 25, 50 mg/kg
Administration:

Oral gavage (p.o.)
Result:

Accelerated gastrointestinal transit in fasted mice.

Animal Model:

Male Sprague-Dawley rat^[5].
Dosage:

10 mg/kg
Administration:

Oral gavage (p.o.)
Result:

Reduced the length of the lesions.

Animal Model:

Male Sprague–Dawley rat^[6].
Dosage:

30 mg/kg
Administration:

Oral gavage (p.o.), once a day for 14 days
Result:

Reduced serum transaminase, lactic dehydrogenase, and γ-glutamyltransferase levels in the CCl₄-treated rats.

Chemical Information

CAS No. 96990-18-0
Appearance Solid
Molecular Weight 764.94
Formula C₄₁H₆₄O₁₃
Color White to off-white
SMILES

CC1(C)CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O[C@]6([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O[C@]7([H])OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)C5(C)C)(C(O)=O)[C@@]3([H])C1
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

All WBCell Proliferation/Viability AssayELISACell Migration/Invasion AssayIn Vivo Efficacy Study

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Journal Impact Factor

Biochem Pharmacol

Momordin Ic suppresses breast cancer growth by targeting ACTL8‑dependent glutamine metabolism and PI3K/AKT/mTOR-MYC. [Abstract]

2026 May:247:117761. PMID: 41621692

Momordin Ic purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 May:247:117761. [Abstract]

Western blot analysis showing ACTL8 protein levels in BC cells treated with DMSO, Momordin Ic, Thiostrepton, XY028-140, MS1943, or dBET1(10 μM each) for 24 h, indicating that Momordin Ic markedly reduced ACTL8 expression, The corresponding protein quantification is shown below.

Momordin Ic purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 May:247:117761. [Abstract]

Cell viability assays revealing the IC50 values of Momordin Ic in BC cells. Dose-response curves and IC₅₀ values of Momordin Ic in MCF-7 and MDA-MB-231 cells transfected with sh-NC or sh-ACTL8.

Momordin Ic purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 May:247:117761. [Abstract]

Glutamine levels were measured using an ELISA kit treated with Momordin Ic (10 μM).

Momordin Ic purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 May:247:117761. [Abstract]

Transwell invasion assays and quantification showing that α-KG supplementation rescued the impaired invasive ability caused by Momordin Ic (10 μM).

Momordin Ic purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 May:247:117761. [Abstract]

Images of subcutaneous xenograft tumors from each treatment group (Control, low-dose Momordin Ic (50 mg/kg), high-dose Momordin Ic (100 mg/kg), α-KG supplementation, and CB-839).
Food Biosci

2024 Oct.
Int J Mol Sci

Cycloastragenol Improves Fatty Acid Metabolism Through NHR-49/FAT-7 Suppression and Potent AAK-2 Activation in Caenorhabditis elegans Obesity Model. [Abstract]

2026 Jan 13;27(2):772. PMID: 41596421
J Pharm Pharmacol

Epidermal growth factor receptor as a potential target of momordin Ic to promote apoptosis of cholangiocarcinoma cells. [Abstract]

2022 Jul 15;74(7):996-1005. PMID: 35640567
J Pharmacol Sci

Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway. [Abstract]

2021 Aug;146(4):249-258. PMID: 34049792

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (130.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3073 mL

6.5365 mL

13.0729 mL

5 mM

0.2615 mL

1.3073 mL

2.6146 mL

10 mM

0.1307 mL

0.6536 mL

1.3073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 6.25 mg/mL (8.17 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mi Y, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42. [Content Brief]

[2]. Wang W, et al. Cytotoxic effects of recombinant proteins enhanced by momordin Ic are dependent on cholesterol and ganglioside GM1. Toxicon. 2023 Jun 15;229:107129. [Content Brief]

[3]. Xianjun F, et al. Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway. J Pharmacol Sci. 2021 Aug;146(4):249-258. [Content Brief]

[4]. Li Y, et al. Acceleration of gastrointestinal transit by momordin Ic in mice: possible involvement of 5-hydroxytryptamine, 5-HT(2) receptors and prostaglandins. Eur J Pharmacol. 2000 Mar 24;392(1-2):71-7. [Content Brief]

[5]. Matsuda H, et al. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65(2):PL27-32. [Content Brief]

[6]. Kim NY, et al. Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3073 mL	6.5365 mL	13.0729 mL	32.6823 mL
	5 mM	0.2615 mL	1.3073 mL	2.6146 mL	6.5365 mL
	10 mM	0.1307 mL	0.6536 mL	1.3073 mL	3.2682 mL
	15 mM	0.0872 mL	0.4358 mL	0.8715 mL	2.1788 mL
	20 mM	0.0654 mL	0.3268 mL	0.6536 mL	1.6341 mL
	25 mM	0.0523 mL	0.2615 mL	0.5229 mL	1.3073 mL
	30 mM	0.0436 mL	0.2179 mL	0.4358 mL	1.0894 mL
	40 mM	0.0327 mL	0.1634 mL	0.3268 mL	0.8171 mL
	50 mM	0.0261 mL	0.1307 mL	0.2615 mL	0.6536 mL
	60 mM	0.0218 mL	0.1089 mL	0.2179 mL	0.5447 mL
	80 mM	0.0163 mL	0.0817 mL	0.1634 mL	0.4085 mL
	100 mM	0.0131 mL	0.0654 mL	0.1307 mL	0.3268 mL

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Momordin Ic

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Terpenoids Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Tibetan Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Momordin Ic

All PI3K Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Momordin Ic Related Classifications

HY-N0330 Related Classifications