Livmoniplimab
Based on 1 Customer Validation
Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 2412004-88-5
- Molecular Weight:146.22 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG4 kappa
Human
TGFB1
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7-week-old female B-hGARP mice subcutaneously inoculated with MC38 mouse colon cancer cells[2].
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.); three times a week; 3 weeks
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Result:Resulted in 34.3% tumor growth inhibition.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Loaded Livmoniplimab on AHC2 biosensor, can bind GARP&Latent TGF Beta-1 Complex Protein, Human (HEK293, His, Strep, HY-P72636) with an affinity constant of 1.675E-09 M as determined in BLI assay. -
Flow Cytometry analysis of PC-3 cells labelling TGFB1 (red) with Livmoniplimab (anti-TGFB1) (HY-P99708). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 2412004-88-5
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Appearance Liquid
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Molecular Weight 146.22 kDa
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Color Colorless to light yellow
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SMILES
[Livmoniplimab]
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Synonyms
ABBV-151; ARGX-115
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Tindall RR, et al. The TGF-β superfamily as potential therapeutic targets in pancreatic cancer. Front Oncol. 2024 Mar 4;14:1362247. [Content Brief]
[2]. Guo J, et al. A novel GARP humanized mouse model for efficacy assessment of GARP-targeting therapies. Int Immunopharmacol. 2024 Mar 30;130:111782. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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