Anti-Mouse CD96 Antibody (3.3)
Based on 1 Customer Validation
Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG1 lambda
Mouse
CD96
Anti-Mouse CD96 Antibody (3.3) (0.0001-100 μg/mL, 48 h) dependently decreases binding of CD155 to CD96 in HEK-293 cells[1].
Anti-Mouse CD96 Antibody (3.3) (24 h) enhances PD-1 blockade to unleash CD8+ tumor infiltrating lymphocytes function in tumor single cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse CD96 Antibody (3.3) (250 μg, i.p., for 4 times) shows potent anti-tumor effect in B16F10/CT26/MCA1956 tumor models[2].
Anti-Mouse CD96 Antibody (3.3) (200 μg, i.p., 2 times a week) significantly delays tumor growth and prolongs the survival in TC-1 tumor-bearing mice models[3].
Anti-Mouse CD96 Antibody (3.3) (250 μg, i.p.) restores inflammatory properties in Th9 cells in allogeneic skin transplantation CD96high mice models[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 experimental metastases mice models[1]
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Dosage:250 μg
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Administration:Intraperitoneally injection, at day 0, 3
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Result:Had significant anti-metastatic activity.
Mediated metastases suppression via NK cells and IFN-γ.
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Animal Model:Orthotopic 4T1.2 mammary carcinoma mice models[1]
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Dosage:400 μg
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Administration:Intraperitoneally injection, at day 12, 14
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Result:Displayed significant anti-metastatic activity.
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Animal Model:B16F10/CT26/MCA1956 tumor models[2]
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Dosage:250 μg
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Administration:Intraperitoneally injection, for 4 times
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Result:Suppressed tumor growth
Enhanced the antitumor efficacy of multiple immune-checkpoint inhibitors.
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Animal Model:TC-1 tumor-bearing C57BL/6 mice models[3]
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Dosage:200 μg
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Administration:Intraperitoneally injection, 2 times a week
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Result:Significantly delayed tumor growth and prolonged the survival.
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Animal Model:Allogeneic skin transplantation CD96high mice models[4]
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Dosage:250 μg
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Administration:Intraperitoneally injection
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Result:Enhanced skin graft inflammation.
Displayed more severe destruction and T-cell infiltration.
Significantly increased T-cell numbers in draining and mesenteric lymph nodes and in the spleen.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo CD96 blocking; in vitro CD96 blocking; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD96 Antibody (3.3)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Roman Aguilera A, et al. CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity. Oncoimmunology. 2018 Feb 1;7(5):e1424677. [Content Brief]
[2]. Mittal D, et al. CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function. Cancer Immunol Res. 2019 Apr;7(4):559-571. [Content Brief]
[3]. Wang Y, et al. Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer. J Immunother Cancer. 2022 Mar;10(3):e003667. [Content Brief]
[4]. Stanko K, et al. CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells. Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2940-E2949. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD96 Antibody (3.3) Related Classifications
HY-P990259 Related Classifications
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