Sodium butyrate-d3
Based on 1 Customer Validation
Sodium butyrate-d3 (Butanoic acid-d3 sodium) is the deuterium labeled Sodium butyrate (HY-B0350A). Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 347840-05-5
- Formula: C4H4D3NaO2
- Molecular Weight:113.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 347840-05-5
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Unlabeled Cas 156-54-7
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Appearance Solid
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Molecular Weight 113.11
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Formula C4H4D3NaO2
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Color White to off-white
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SMILES
O=C(CCC([2H])([2H])[2H])O[Na]
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Synonyms
Butanoic acid-d3 sodium; Butyric acid-d3 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 75 mg/mL (663.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34 [Content Brief]
[2]. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27 [Content Brief]
[3]. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230 [Content Brief]
[4]. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929 [Content Brief]
[5]. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.8410 mL | 44.2048 mL | 88.4095 mL | 221.0238 mL |
| 5 mM | 1.7682 mL | 8.8410 mL | 17.6819 mL | 44.2048 mL | |
| 10 mM | 0.8841 mL | 4.4205 mL | 8.8410 mL | 22.1024 mL | |
| 15 mM | 0.5894 mL | 2.9470 mL | 5.8940 mL | 14.7349 mL | |
| 20 mM | 0.4420 mL | 2.2102 mL | 4.4205 mL | 11.0512 mL | |
| 25 mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 8.8410 mL | |
| 30 mM | 0.2947 mL | 1.4735 mL | 2.9470 mL | 7.3675 mL | |
| 40 mM | 0.2210 mL | 1.1051 mL | 2.2102 mL | 5.5256 mL | |
| 50 mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 4.4205 mL | |
| 60 mM | 0.1473 mL | 0.7367 mL | 1.4735 mL | 3.6837 mL | |
| 80 mM | 0.1105 mL | 0.5526 mL | 1.1051 mL | 2.7628 mL | |
| 100 mM | 0.0884 mL | 0.4420 mL | 0.8841 mL | 2.2102 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium butyrate-d3 Related Classifications
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