2. Epigenetics Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. Histone Acetyltransferase Estrogen Receptor/ERR CDK
  4. OP-3136

OP-3136 is a selective KAT6 inhibitor. OP-3136 reduces the proliferative capacity of cancer cells and inhibits cell growth in ER+ breast cancer cell models with overexpressed KAT6. When combined with ER antagonists/degraders or CDK4/6 inhibitors, OP-3136 exhibits synergistic anti-tumor activity in mouse xenograft models. OP-3136 can be used in studies related to HR+/HER2- breast cancer.

For research use only. We do not sell to patients.

OP-3136

OP-3136 Chemical Structure

CAS No. : 3056105-63-3

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1 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
5 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
10 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
25 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
50 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
100 mg Get quote 7 - 9 Weeks 6 - 8 Weeks 8 - 10 Weeks 7 - 9 weeks
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

OP-3136 Related Antibodies

Top Publications Citing Use of Products

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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  • Customer Review

Description

OP-3136 is a selective KAT6 inhibitor. OP-3136 reduces the proliferative capacity of cancer cells and inhibits cell growth in ER+ breast cancer cell models with overexpressed KAT6. When combined with ER antagonists/degraders or CDK4/6 inhibitors, OP-3136 exhibits synergistic anti-tumor activity in mouse xenograft models. OP-3136 can be used in studies related to HR+/HER2- breast cancer[1].

IC50 & Target[1]

CDK4

 

CDK6

 

KAT6

 

In Vitro

OP-3136 reduces the proliferation of breast cancer cell lines and inhibits growth in KAT6-overexpressing ER+ breast cancer cell models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OP-3136 Related Antibodies
In Vivo

OP-3136 shows synergistic
activity when combined with either ER antagonist/degraders (including
Palazestrant (HY-148789)) or CDK4/6 inhibitors such as Ribociclib (HY-15777) in a mouse xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

462.48

Formula

C20H22N4O7S
CAS No.
SMILES

COC1=CC(OC)=C(C(OC)=C1)S(=O)(NC(C2=NC(OC)=C(C=C2)CN3C=CC=N3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OP-3136 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OP-31363056105-63-3OP3136OP 3136Histone AcetyltransferaseEstrogen Receptor/ERRCDKHATsHATCyclin dependent kinasecancer cell proliferationbreast cancer cell linesER+ cell modelsKAT6antitumor effectsmouse xenograft modelsCDK4/6 inhibitorsHR+/HER2- breast cancerER antagonist/degradersInhibitorinhibitorinhibit

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