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Cat. No.: HY-181816

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PD-1/PD-L1-IN-60

PD-1/PD-L1-IN-60 is the counterpart of the small-molecule immuno-probe [¹⁸F] LG‑8, and the two together enable integrated immuno-diagnosis and therapy. PD-1/PD-L1-IN-60 exhibits potent anti-tumor activity in mouse models of melanoma and lung cancer with high PD‑L1 uptake. PD-1/PD-L1-IN-60 can be used for relevant research on melanoma and lung cancer.

For research use only. We do not sell to patients.

CAS No.: 3095344-37-6
Formula: C₅₃H₇₀ClFN₄O₁₅
Molecular Weight:1057.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PD-1/PD-L1-IN-60 Chemical Structure

CAS No.: 3095344-37-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vivo

PD-1/PD-L1-IN-60 (LG-8) (2 mg/kg; i.p.; administered every other day; total 7 doses) exhibits potent anti-tumor activity in the B16−F10 melanoma mice model^[1].
PD-1/PD-L1-IN-60 (2 mg/kg; i.p.; administered once every other day for a total of 4 doses) exhibits significant anti-tumor efficacy in a Cisplatin (HY-17394)-induced PD-L1-overexpressing LLC lung cancer mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female)^[1]
Dosage:

2 mg/kg
Administration:

i.p.; every other day; 7 total doses
Result:

Reduced mean tumor volume to 110 mm³ .
Markedly diminished PD-L1 expression in tumors.
Significantly enhanced CD8⁺ T-cell infiltration relative to control.
Caused a slight increase in body weight with no significant difference from controls.

Animal Model:

C57BL/6 (female)^[1]
Dosage:

2 mg/kg
Administration:

i.p.; every other day; 4 total doses
Result:

Reduced mean tumor volume to 1129 mm³ in PD-L1 high-expression subgroup.
Caused no significant weight loss in treated mice.

Chemical Information

CAS No. 3095344-37-6
Molecular Weight 1057.59
Formula C₅₃H₇₀ClFN₄O₁₅
SMILES

OCC(CO)(CO)N(CC1=CN(CCOCCOCCOCCOCCOCCOCCOCCF)N=N1)CC(C(OCC2=CC(O)=CC=C2)=C3)=CC(Cl)=C3OCC4=C(C)C(C5=CC6=C(OCCO6)C=C5)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lv G, et al. Development of PD-L1 Targeting Small-Molecule Immunotheranostic Agents for Personalized Antitumor Immunotherapy. J Med Chem. 2026;69(4):4602-4612. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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