2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-60

PD-1/PD-L1-IN-60 is the counterpart of the small-molecule immuno-probe [18F] LG‑8, and the two together enable integrated immuno-diagnosis and therapy. PD-1/PD-L1-IN-60 exhibits potent anti-tumor activity in mouse models of melanoma and lung cancer with high PD‑L1 uptake. PD-1/PD-L1-IN-60 can be used for relevant research on melanoma and lung cancer.

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PD-1/PD-L1-IN-60

PD-1/PD-L1-IN-60 Chemical Structure

CAS No. : 3095344-37-6

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PD-1/PD-L1-IN-60 Related Antibodies

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Description

PD-1/PD-L1-IN-60 is the counterpart of the small-molecule immuno-probe [18F] LG‑8, and the two together enable integrated immuno-diagnosis and therapy. PD-1/PD-L1-IN-60 exhibits potent anti-tumor activity in mouse models of melanoma and lung cancer with high PD‑L1 uptake. PD-1/PD-L1-IN-60 can be used for relevant research on melanoma and lung cancer[1].

In Vivo

PD-1/PD-L1-IN-60 (LG-8) (2 mg/kg; i.p.; administered every other day; total 7 doses) exhibits potent anti-tumor activity in the B16−F10 melanoma mice model[1].
PD-1/PD-L1-IN-60 (2 mg/kg; i.p.; administered once every other day for a total of 4 doses) exhibits significant anti-tumor efficacy in a Cisplatin (HY-17394)-induced PD-L1-overexpressing LLC lung cancer mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female)[1]
Dosage: 2 mg/kg
Administration: i.p.; every other day; 7 total doses
Result: Reduced mean tumor volume to 110 mm3 .
Markedly diminished PD-L1 expression in tumors.
Significantly enhanced CD8+ T-cell infiltration relative to control.
Caused a slight increase in body weight with no significant difference from controls.
Animal Model: C57BL/6 (female)[1]
Dosage: 2 mg/kg
Administration: i.p.; every other day; 4 total doses
Result: Reduced mean tumor volume to 1129 mm3 in PD-L1 high-expression subgroup.
Caused no significant weight loss in treated mice.
Molecular Weight

1057.59

Formula

C53H70ClFN4O15
CAS No.
SMILES

OCC(CO)(CO)N(CC1=CN(CCOCCOCCOCCOCCOCCOCCOCCF)N=N1)CC(C(OCC2=CC(O)=CC=C2)=C3)=CC(Cl)=C3OCC4=C(C)C(C5=CC6=C(OCCO6)C=C5)=CC=C4
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Purity & Documentation
References
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PD-1/PD-L1-IN-60 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-603095344-37-6PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1 inhibitormelanomalung cancerC57BL/6 mice
Inhibitorinhibitorinhibit

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