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Referencia número: HY-175831

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BRAFV600E-IN-2

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3027070-47-6
Fòrmula: C₂₃H₂₀F₃N₅O₄S
Peso molecular:519.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BRAFV600E-IN-2 Chemical Structure

No. CAS: 3027070-47-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity^[1].

IC₅₀ & Target

BRAF-V600E

<10 nM (IC₅₀)

Ver todos los productos específicos de isoformas Raf :

In Vitro

BRAFV600E-IN-2 (compound 10) (72 h) has an IC₅₀ ≤10 nM for A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_dss	AUC_0-t	F	Brain-to-Plasma Ratio	T_1/2
Dog^[1]	0.5 mg/kg	i.v.	0.425 mL/min/kg	0.155 L/kg	40879 ng·h/mL	/	/	/
Mice^[1]	10 mg/kg	i.g.	/	/	914322 ng·h/mL	83.9 %	0.0107	11.8 h
Mice^[1]	2.5 mg/kg	i.v.	0.117 mL/min/kg	0.111 L/kg	272309 ng·h/mL	/	/	12 h

Chemical Information

No. CAS 3027070-47-6
Peso molecular 519.50
Fòrmula C₂₃H₂₀F₃N₅O₄S
SMILES

N#CC(C(NS(=O)(N1CC2(C1)CCC2)=O)=CC=C3F)=C3OC(C=C4)=CC(C5=O)=C4N=CN5CC(F)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Li yao, et al. Preparation and use of quinazolinone derivative as kinase inhibitor. Preparation and use of quinazolinone derivative as kinase inhibitor. WO2024017294A1. 2024-01-25.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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