country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-175831

Copy Link Print Information

BRAFV600E-IN-2

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3027070-47-6
Formule: C₂₃H₂₀F₃N₅O₄S
Masse moléculaire:519.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BRAFV600E-IN-2 Chemical Structure

CAS No.: 3027070-47-6

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity^[1].

IC₅₀ & Target

BRAF-V600E

<10 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Raf :

In Vitro

BRAFV600E-IN-2 (compound 10) (72 h) has an IC₅₀ ≤10 nM for A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_dss	AUC_0-t	F	Brain-to-Plasma Ratio	T_1/2
Dog^[1]	0.5 mg/kg	i.v.	0.425 mL/min/kg	0.155 L/kg	40879 ng·h/mL	/	/	/
Mice^[1]	10 mg/kg	i.g.	/	/	914322 ng·h/mL	83.9 %	0.0107	11.8 h
Mice^[1]	2.5 mg/kg	i.v.	0.117 mL/min/kg	0.111 L/kg	272309 ng·h/mL	/	/	12 h

Chemical Information

CAS No. 3027070-47-6
Masse moléculaire 519.50
Formule C₂₃H₂₀F₃N₅O₄S
SMILES

N#CC(C(NS(=O)(N1CC2(C1)CCC2)=O)=CC=C3F)=C3OC(C=C4)=CC(C5=O)=C4N=CN5CC(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li yao, et al. Preparation and use of quinazolinone derivative as kinase inhibitor. Preparation and use of quinazolinone derivative as kinase inhibitor. WO2024017294A1. 2024-01-25.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

BRAFV600E-IN-2

Voir tous les produits spécifiques à Isoform Raf

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BRAFV600E-IN-2 Related Classifications

HY-175831 Related Classifications