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Cat. No.: HY-175831

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BRAFV600E-IN-2

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 3027070-47-6
Formula: C₂₃H₂₀F₃N₅O₄S
Molecular Weight:519.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BRAFV600E-IN-2 Chemical Structure

CAS No.: 3027070-47-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC₅₀ ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity^[1].

IC₅₀ & Target

BRAF-V600E

<10 nM (IC₅₀)

All Raf Isoforms :

In Vitro

BRAFV600E-IN-2 (compound 10) (72 h) has an IC₅₀ ≤10 nM for A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_dss	AUC_0-t	F	Brain-to-Plasma Ratio	T_1/2
Dog^[1]	0.5 mg/kg	i.v.	0.425 mL/min/kg	0.155 L/kg	40879 ng·h/mL	/	/	/
Mice^[1]	10 mg/kg	i.g.	/	/	914322 ng·h/mL	83.9 %	0.0107	11.8 h
Mice^[1]	2.5 mg/kg	i.v.	0.117 mL/min/kg	0.111 L/kg	272309 ng·h/mL	/	/	12 h

Chemical Information

CAS No. 3027070-47-6
Molecular Weight 519.50
Formula C₂₃H₂₀F₃N₅O₄S
SMILES

N#CC(C(NS(=O)(N1CC2(C1)CCC2)=O)=CC=C3F)=C3OC(C=C4)=CC(C5=O)=C4N=CN5CC(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li yao, et al. Preparation and use of quinazolinone derivative as kinase inhibitor. Preparation and use of quinazolinone derivative as kinase inhibitor. WO2024017294A1. 2024-01-25.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BRAFV600E-IN-2

All Raf Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BRAFV600E-IN-2 Related Classifications

HY-175831 Related Classifications