2. MAPK/ERK Pathway
  3. Raf
  4. BRAFV600E-IN-2

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC50 ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity.

For research use only. We do not sell to patients.

BRAFV600E-IN-2

BRAFV600E-IN-2 Chemical Structure

CAS No. : 3027070-47-6

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BRAFV600E-IN-2 Related Antibodies

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Description

BRAFV600E-IN-2 is a BRAF V600E inhibitor with IC50 ≤10 nM. BRAFV600E-IN-2 has anti-tumor activity[1].

IC50 & Target

BRAF-V600E

<10 nM ()

In Vitro

BRAFV600E-IN-2 (compound 10) (72 h) has an IC50 ≤10 nM for A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRAFV600E-IN-2 Related Antibodies
Parmacokinetics
Species Dose Route CL Vdss AUC0-t F Brain-to-Plasma Ratio T1/2
Dog[1] 0.5 mg/kg i.v. 0.425 mL/min/kg 0.155 L/kg 40879 ng·h/mL / / /
Mice[1] 10 mg/kg i.g. / / 914322 ng·h/mL 83.9 % 0.0107 11.8 h
Mice[1] 2.5 mg/kg i.v. 0.117 mL/min/kg 0.111 L/kg 272309 ng·h/mL / / 12 h
Molecular Weight

519.50

Formula

C23H20F3N5O4S
CAS No.
SMILES

N#CC(C(NS(=O)(N1CC2(C1)CCC2)=O)=CC=C3F)=C3OC(C=C4)=CC(C5=O)=C4N=CN5CC(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRAFV600E-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRAFV600E-IN-23027070-47-6RafRaf kinasesBRAFInhibitoranti-tumorinhibitorinhibit

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HY-175831
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