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Cat. No.: HY-137450A

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Senaparib hydrochloride

(Synonyms: IMP4297 hydrochloride; JS109 hydrochloride)

Senaparib hydrochloride (IMP4297 hydrochloride) is an oral, selective PARP1/2 inhibitor with potent anti-tumor activity. Senaparib hydrochloride shows antitumor activity against advanced ovarian cancer.

For research use only. We do not sell to patients.

CAS No.: 1401683-39-3
Formula: C₂₄H₂₁ClF₂N₆O₃
Molecular Weight:514.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Senaparib hydrochloride Chemical Structure

CAS No.: 1401683-39-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PARP Isoforms :

Chemical Information

CAS No. 1401683-39-3
Molecular Weight 514.91
Formula C₂₄H₂₁ClF₂N₆O₃
SMILES

O=C1NC(N(CC2=CC=C(C(C(N3CCN(CC3)C4=NC=CC=N4)=O)=C2)F)C5=C1C(F)=CC=C5)=O.Cl
Synonyms

IMP4297 hydrochloride; JS109 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. P. de Souza, et al. 574P Updated results of phase I study of senaparib (IMP4297) in Australian patients with advanced solid tumours. ABSTRACT ONLY| VOLUME 31, SUPPLEMENT 4, S490, SEPTEMBER 01, 2020.

[2]. Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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