Anti-Mouse IL-10 Antibody (JES5-2A5)
Based on 1 publication(s) in Google Scholar
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM).
For research use only. We do not sell to patients.
- Purity : 98.666%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse IL-10 Antibody (JES5-2A5)
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Biological Activity
Description
Isotype
Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Mouse
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IL-10 |
In Vitro
Anti-Mouse IL-10 Antibody (JES5-2A5) (24 h) restores the anti-tumor activity of IL-6 and enhances the efficacy of Mifamurtide (HY-13682) by blocking the IL-10/SOCS3 axis in MG-63, HOS and 143B cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse IL-10 Antibody (JES5-2A5) (250 μg, i.v., twice a week) significantly reduces the density of cerebral capillary occlusion in C57BL/6J mice with a Streptozotocin (STZ) (HY-13753) induced type 1 diabetes mellitus (T1DM) model[2].
Anti-Mouse IL-10 Antibody (JES5-2A5) (300 μg, i.p., single dose, 1 h after cell injection) significantly reduces tumor cell retention in the lungs combined with Mifamurtide (HY-13682) in BALB/c mice bearing K7M2 tumors[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SJL mice with an EAE (8-12 weeks)[1]
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Dosage:200 μg
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Administration:Intraperitoneal injection (i.p.), twice a week from the day 6 after immunization
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Result:Weakened the protective effect of MaR1.
Increased IL-17+CD4+ T cells infiltration.
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Animal Model:STZ (75 mg/kg) injected C57BL/6J mice (2-6 months)[2]
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Dosage:250 μg
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Administration:Intravenous injection (i.v.), twice a week
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Result:Significantly reduced the density of blocked capillaries in different brain regions.
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Animal Model:1×106 K7M2 cells injected BALB/c mice (6 weeks)[3]
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Dosage:300 μg, combined with Mifamurtide (30 μg)
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Administration:Intraperitoneal injection (i.p.), single dose 1 h after cell injection
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Result:Significantly reduced lung metastasis of tumor cells.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo IL-10 neutralization; in vitro IL-10 neutralization
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-10 Antibody (JES5-2A5)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Zahoor I, et al. Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of multiple sclerosis. J Biol Chem. 2025 Mar;301(3):108226. [Content Brief]
[2]. Sharma S, et al. A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes. Nat Metab. 2024 Nov;6(11):2082-2099. [Content Brief]
[3]. Nastasi N, et al. Blockade of IL-10 Signaling Ensures Mifamurtide Efficacy in Metastatic Osteosarcoma. Cancers (Basel). 2023 Sep 27;15(19):4744. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-10 Antibody (JES5-2A5) Related Classifications
HY-P990001 Related Classifications
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