Anti-Mouse CD19 Antibody (1D3)
Based on 1 Customer Validation
Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells.
For research use only. We do not sell to patients.
- Purity: 98.778%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (timed pregnant, neonatal pups, 8-week-old adults, 6-month-old adults); BALB/c.nu (8-12-week-old, 12-week-old)[1]
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Dosage:400 μg (immune response study); 500 μg (perinatal study, adult B-1a maintenance study, B-1a replication study)
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Administration:i.p.; every other day (gestation day 9 until birth for pregnant mice; 4 to 32 days for 8-week-old BALB/c and 8-12-week-old BALB/c.nu mice; 8 days for 6-month-old BALB/c mice; 12 days for 12-week-old BALB/c.nu mice); single dose at 10 days of age for pups
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Result:Down-regulated CD19 expression on B cells.
Reduced splenic and peritoneal B-1a cells at 4, 9, and 23 days of age in neonates.
Reduced B-2 cells by 40% at day 4, which recovered to 92-98% of control levels by days 9 and 23 in neonates.
Reduced splenic T cells by 46% at day 4, which recovered by day 23 in neonates.
Reduced peritoneal B-1a cells gradually to 40% of control levels after 4.5 weeks of adult treatment.
Left splenic B-2 cell recovery and bone marrow B cell precursor populations in BALB/c.nu mice unchanged.
Reduced total peritoneal B-1a cells to 73% of control levels in 6-month-old mice.
Reduced BrdUrd-positive B-1a cells by 60%, while leaving BrdUrd-negative B-1a cell numbers unchanged.
P25918
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo B cell depletion; in vivo CD19 neutralization; in vitro B cell negative selection; Flow c
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD19 Antibody (1D3)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD19 Antibody (1D3) Related Classifications
HY-P99976 Related Classifications
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