Anti-Mouse CD19 Antibody (1D3)
Based on 1 Customer Validation
Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells.
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- Purity: 98.778%
- 분자량:150 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Rat IgG2a kappa
Mouse
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (timed pregnant, neonatal pups, 8-week-old adults, 6-month-old adults); BALB/c.nu (8-12-week-old, 12-week-old)[1]
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Dosage:400 μg (immune response study); 500 μg (perinatal study, adult B-1a maintenance study, B-1a replication study)
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Administration:i.p.; every other day (gestation day 9 until birth for pregnant mice; 4 to 32 days for 8-week-old BALB/c and 8-12-week-old BALB/c.nu mice; 8 days for 6-month-old BALB/c mice; 12 days for 12-week-old BALB/c.nu mice); single dose at 10 days of age for pups
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Result:Down-regulated CD19 expression on B cells.
Reduced splenic and peritoneal B-1a cells at 4, 9, and 23 days of age in neonates.
Reduced B-2 cells by 40% at day 4, which recovered to 92-98% of control levels by days 9 and 23 in neonates.
Reduced splenic T cells by 46% at day 4, which recovered by day 23 in neonates.
Reduced peritoneal B-1a cells gradually to 40% of control levels after 4.5 weeks of adult treatment.
Left splenic B-2 cell recovery and bone marrow B cell precursor populations in BALB/c.nu mice unchanged.
Reduced total peritoneal B-1a cells to 73% of control levels in 6-month-old mice.
Reduced BrdUrd-positive B-1a cells by 60%, while leaving BrdUrd-negative B-1a cell numbers unchanged.
P25918
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo B cell depletion; in vivo CD19 neutralization; in vitro B cell negative selection; Flow c
Chemical Information
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Appearance Liquid
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분자량 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD19 Antibody (1D3)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)