2. Gene
  3. Il10 - interleukin 10 Gene

Il10 - interleukin 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CSIF; If2a; Il-10

Gene ID: 16153 | Gene type: protein coding

About Il10

Chromosome 1: 130,947,582-130,952,711 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 193 orthologues, 3 paralogues and is associated with 137 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 Infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]

Il10 Products(1)

mRNA Protein Name
NM_010548.2 NP_034678.1 interleukin-10 precursor

Il10 Protein Structure

IL10

IL10: pfam00726 (14 - 173)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

interleukin-10

cytokine synthesis inhibitory factor

interferon 2a

Recombinant Il10 Proteins

Cat. No. Product Name Accession Purity
HY-P7074A IL-10 Protein, Mouse (CHO) P18893 (S19-S178) ≥95%
HY-P7567 Recombinant Mouse Interleukin-10 P18893 /
HY-P70517 IL-10 Protein, Mouse P18893 (S19-S178) ≥95%
HY-P700188AF Animal-Free IL-10 Protein, Mouse (His) P18893 (S19-S178) ≥95%

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0809 Theophylline 99.89% Yes
HY-107909 Theophylline sodium glycinate / Unkown
HY-B0809B Theophylline sodium acetate / Unkown
HY-B0809R Theophylline (Standard) / Unkown
HY-B0809A Theophylline monohydrate / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-101019 Ossirene ≥98.0% Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-15507 VGX-1027 Inhibitor 99.76% Phase 1
Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110133 JTE-607 Inhibitor 99.27% Unkown
HY-141537 ABR-238901 Inhibitor 99.25% Unkown
HY-110353 CU-T12-9 Agonist 98.94% Unkown
HY-N0405 Orientin Inhibitor 99.02% Unkown
HY-N6607 Tryptanthrin 99.89% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-122586 BRD6989 99.56% Unkown
HY-N7176 Kaempferol 3-O-β-D-glucuronide Modulator 99.41% Unkown
HY-113402A Gamma-glutamylcysteine TFA 95.20% Unkown
HY-N0600 Ginsenoside F3 Modulator 99.84% Unkown
HY-N1940 β-Anhydroicaritin 99.09% Unkown
HY-P1194 Spantide I Antagonist 99.85% Unkown
HY-150232 MALT1-IN-11 Inhibitor / Unkown
HY-P1194A Spantide I TFA Antagonist 99.32% Unkown
HY-101757 NO-prednisolone Agonist ≥99.0% Unkown
HY-23119 Sodium thiocyanate, GR, 99% ≥99.0% Unkown
HY-160040A Cobitolimod sodium Agonist / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-147105 LRH-1 modulator-1 Modulator / Unkown
HY-147506 NOD2 antagonist 1 Antagonist / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-149365 SIKs-IN-1 Inhibitor / Unkown
HY-155520 Antileishmanial agent-19 Inhibitor / Unkown
HY-160040 Cobitolimod Agonist / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-RS06670 IL10 Human Pre-designed siRNA Set A / Unkown
HY-RS06671 Il10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06672 Il10 Rat Pre-designed siRNA Set A / Unkown
HY-RS06673 IL10RA Human Pre-designed siRNA Set A / Unkown
HY-RS06674 IL10RB Human Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990001 Anti-Mouse IL-10 Antibody Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il10 NCBI NCBI:3586
Macaca fascicularis Il10 NCBI NCBI:102133450
Susscrofa domestica Il10 NCBI
Rattus norvegicus Il10 NCBI NCBI:25325