PF-07899895
Based on 1 Customer Validation
PF-07899895 (Compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM, and 1.8 nM against SIK1, SIK2, and SIK3, respectively. PF-07899895 modulates the anti-inflammatory cytokine IL-10 in immune cells. PF-07899895 is applicable to research related to inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 3033846-10-2
- Formula: C23H23N5OS
- Molecular Weight:417.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-10 |
PF-07899895 is a salt-inducible kinase (SIK) inhibitor with potent activity, with IC50 values of 1.2 nM, 0.9 nM and 1.8 nM against SIK1, SIK2 and SIK3, respectively[2].
PF-07899895 (~38 pM-~10 μM) modulates the pro-inflammatory (TNF-α) and anti-inflammatory (IL-10) cytokine profiles in immune cells, with an IC50 of 6.9 nM for TNF-α and an EC50 of 28 nM for IL-10[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 3033846-10-2
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Appearance Solid
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Molecular Weight 417.53
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Formula C23H23N5OS
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Color Light yellow to yellow
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SMILES
N#CC1=CC=CC2=NC=C(N12)C3=CC(SC)=C(C#N)C(OCC4(CCCCC4)N)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (119.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3950 mL | 11.9752 mL | 23.9504 mL | 59.8759 mL |
| 5 mM | 0.4790 mL | 2.3950 mL | 4.7901 mL | 11.9752 mL | |
| 10 mM | 0.2395 mL | 1.1975 mL | 2.3950 mL | 5.9876 mL | |
| 15 mM | 0.1597 mL | 0.7983 mL | 1.5967 mL | 3.9917 mL | |
| 20 mM | 0.1198 mL | 0.5988 mL | 1.1975 mL | 2.9938 mL | |
| 25 mM | 0.0958 mL | 0.4790 mL | 0.9580 mL | 2.3950 mL | |
| 30 mM | 0.0798 mL | 0.3992 mL | 0.7983 mL | 1.9959 mL | |
| 40 mM | 0.0599 mL | 0.2994 mL | 0.5988 mL | 1.4969 mL | |
| 50 mM | 0.0479 mL | 0.2395 mL | 0.4790 mL | 1.1975 mL | |
| 60 mM | 0.0399 mL | 0.1996 mL | 0.3992 mL | 0.9979 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2994 mL | 0.7484 mL | |
| 100 mM | 0.0240 mL | 0.1198 mL | 0.2395 mL | 0.5988 mL |
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