3033846-10-2
3033846-10-2
Chemical Structure
PF-07899895
- CAS No.: 3033846-10-2
- Formula:C23H23N5OS
- Molecular Weight:417.53
InChIKey: LTQKUGJNXFIXKC-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC2=NC=C(N12)C3=CC(SC)=C(C#N)C(OCC4(CCCCC4)N)=C3
Biological Activity: PF-07899895 (Compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM, and 1.8 nM against SIK1, SIK2, and SIK3, respectively. PF-07899895 modulates the anti-inflammatory cytokine IL-10 in immune cells. PF-07899895 is applicable to research related to inflammatory diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-07899895 | 98.83% | PF-07899895 (Compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM, and 1.8 nM against SIK1, SIK2, and SIK3, respectively. PF-07899895 modulates the anti-inflammatory cytokine IL-10 in immune cells. PF-07899895 is applicable to research related to inflammatory diseases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-161442SIK-IN-3 -
Similarity Score 0.82
HY-161441SIK-IN-2 -
Similarity Score 0.79
HY-161440SIK-IN-1 -
Similarity Score 0.42
HY-13060ACHP Hydrochloride -
Similarity Score 0.41
HY-103512TP003 -
Similarity Score 0.41
HY-162649TIC10g -
Similarity Score 0.41
HY-107592ACHP -
Similarity Score 0.41
HY-13961GLPG0634 analog -
Similarity Score 0.41
HY-107978RRIPK-IN-4 (Standard) -
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