2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TP003

TP003 

Cat. No.: HY-103512 Purity: 98.99%
COA Handling Instructions

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors.

For research use only. We do not sell to patients.

TP003 Chemical Structure

TP003 Chemical Structure

CAS No. : 628690-75-5

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10 mg USD 240 In-stock
25 mg USD 500 In-stock
50 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

TP003 Related Antibodies

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Description

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

Molecular Weight

407.39

Appearance

Solid

Formula

C23H16F3N3O
CAS No.
SMILES

N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (245.47 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4547 mL 12.2733 mL 24.5465 mL
5 mM 0.4909 mL 2.4547 mL 4.9093 mL
10 mM 0.2455 mL 1.2273 mL 2.4547 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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TP003 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

TP003628690-75-5TP 003TP-003GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorbenzodiazepineα1β2γ2α2β3γ2α3β3γ2α5β2γ2anxiolysisInhibitorinhibitorinhibit

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