1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. TP003

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors.

For research use only. We do not sell to patients.

TP003 Chemical Structure

TP003 Chemical Structure

CAS No. : 628690-75-5

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 500 In-stock
50 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

Molecular Weight

407.39

Formula

C23H16F3N3O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (245.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4547 mL 12.2733 mL 24.5465 mL
5 mM 0.4909 mL 2.4547 mL 4.9093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4547 mL 12.2733 mL 24.5465 mL 61.3663 mL
5 mM 0.4909 mL 2.4547 mL 4.9093 mL 12.2733 mL
10 mM 0.2455 mL 1.2273 mL 2.4547 mL 6.1366 mL
15 mM 0.1636 mL 0.8182 mL 1.6364 mL 4.0911 mL
20 mM 0.1227 mL 0.6137 mL 1.2273 mL 3.0683 mL
25 mM 0.0982 mL 0.4909 mL 0.9819 mL 2.4547 mL
30 mM 0.0818 mL 0.4091 mL 0.8182 mL 2.0455 mL
40 mM 0.0614 mL 0.3068 mL 0.6137 mL 1.5342 mL
50 mM 0.0491 mL 0.2455 mL 0.4909 mL 1.2273 mL
60 mM 0.0409 mL 0.2046 mL 0.4091 mL 1.0228 mL
80 mM 0.0307 mL 0.1534 mL 0.3068 mL 0.7671 mL
100 mM 0.0245 mL 0.1227 mL 0.2455 mL 0.6137 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TP003
Cat. No.:
HY-103512
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