Ganglioside GT1b (bovine) trisodium
Ganglioside GT1b bovine trisodium is a trisialic acid ganglioside. Ganglioside GT1b bovine trisodium binds to botulinum toxin type A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively. Ganglioside GT1b bovine trisodium acts as a TLR2 agonist, leading to microglial activation, increased expression of pro-inflammatory factors, and increased pain sensitivity in spinal microglia. Ganglioside GT1b bovine trisodium also reduces the production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs). Ganglioside GT1b bovine trisodium increases extracellular glutamate levels in neural cell models. Ganglioside GT1b bovine trisodium has potential applications in research on immune system diseases and nervous system diseases.
For research use only. We do not sell to patients.
- Formula: C95H162N5Na3O47
- Molecular Weight:2195.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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Molecular Weight 2195.28
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Formula C95H162N5Na3O47
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SMILES
CCCCCCCCCCCCC/C=C/[C@]([C@]([H])(CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O[C@]5(O[C@@H]([C@@H]([C@@H](CO)O)O)[C@H](NC(C)=O)[C@@H](O)C5)C(O[Na])=O)[C@H]4O)[C@@H](O)[C@@H](CO)O3)[C@H](O[C@]6(O[C@@H]([C@@H]([C@@H](CO)O[C@]7(O[C@@H]([C@@H]([C@@H](CO)O)O)[C@H](NC(C)=O)[C@@H](O)C7)C(O[Na])=O)O)[C@H](NC(C)=O)[C@@H](O)C6)C(O[Na])=O)[C@H]2O)[C@@H](CO)O1)NC(CCCCCCCCCCCCCCCCC)=O)(O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lim H, et al. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. EMBO J. 2020 Mar 16;39(6):e102214. [Content Brief]
[2]. Schengrund CL, et al. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof. J Neurochem. 1991 Sep;57(3):1024-32. [Content Brief]
[3]. Erickson KD, et al. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol. 2009 Oct;83(19):10275-9. [Content Brief]
[4]. Kanda N, et al. Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. Immunology. 1999 Apr;96(4):628-33. [Content Brief]
[5]. Watanabe S, et al. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neurosci Lett. 2012 May 31;517(2):140-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ganglioside GT1b (bovine) trisodium Related Classifications
HY-175073 Related Classifications
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