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  3. PI3K
  4. Gallein

Gallein  (Synonyms: Pyrogallol phthalein)

Cat. No.: HY-D0254 Purity: ≥98.0%
COA Handling Instructions

Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent. Gallein used as a red dye, an acid-base indicator and as a detection reagent for phosphates.

For research use only. We do not sell to patients.

Gallein Chemical Structure

Gallein Chemical Structure

CAS No. : 2103-64-2

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
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10 mM * 1 mL
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10 mg USD 75 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent[1]. Gallein used as a red dye, an acid-base indicator and as a detection reagent for phosphates[2].

Molecular Weight

364.31

Appearance

Solid

Formula

C20H12O7
CAS No.
SMILES

O=C1OC2(C3=C(OC4=C2C=CC(O)=C4O)C(O)=C(O)C=C3)C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (91.49 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7449 mL 13.7246 mL 27.4492 mL
5 mM 0.5490 mL 2.7449 mL 5.4898 mL
10 mM 0.2745 mL 1.3725 mL 2.7449 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Gallein2103-64-2Pyrogallol phthaleinPI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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