Tubulin inhibitor 36
Tubulin inhibitor 36 (Compound 10) is a novel and potent tubulin inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC50 value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research.
For research use only. We do not sell to patients.
- Formula: C16H13ClN6S
- Molecular Weight:356.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Tubulin inhibitor 36 (Compound 10) exhibits antiproliferative activities against human tumor cell lines, and the IC50 value is 0.039, 0.038, 0.022, 0.025, 0.037, 0.040, 0.059 μM for HeLa, MCF7, U87 MG, T98G, HepG2, HCT8, HT-29 cells, respectively[1]. Tubulin inhibitor 36 (Compound 10) (100 nM, 24 h, 48 h, 72 h) arrests mitotic and apoptosis in HeLa, MCF7, and U87 MG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, MCF7, U87 MG cells
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Concentration:100 nM
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Incubation Time:24 h
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Result:Arrested tubulin polymerization in HeLa, MCF7, and U87 MG cells.
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Cell Line:HeLa, MCF7, U87 MG cells
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Concentration:100 nM
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Incubation Time:24 h, 48 h, 72 h
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Result:Induced remarkable mitotic arrest in 24 h of HeLa cells.
Induced mitotic arrest in 24 h of MCF7 cells but lower cell death compared to HeLa cells
Induced remarkable mitotic arrest in 24 h of U87 MG cells and severe cell death.
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Cell Line:HeLa, MCF7, U87 MG cells
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Concentration:100 nM
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Incubation Time:72 h
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Result:Induced nearly 73% of apoptosis in 72 h of HeLa cells and lower levels of MCF7 cells
Induced lower cell death levels of MCF7 cells
Displayed the highest cell death levels of d U87 MG cells
Chemical Information
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Molecular Weight 356.83
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Formula C16H13ClN6S
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SMILES
CN1C=CC2=C1C=CC(N3N=NN=C3C4=CC(Cl)=NC(SC)=C4)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 36 Related Classifications
HY-149374 Related Classifications
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