Tubulin inhibitor 36

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Tubulin inhibitor 36 (Compound 10) is a novel and potent tubulin inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC₅₀ value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research.

For research use only. We do not sell to patients.

Tubulin inhibitor 36 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Tubulin inhibitor 36 (Compound 10) exhibits antiproliferative activities against human tumor cell lines, and the IC₅₀ value is 0.039, 0.038, 0.022, 0.025, 0.037, 0.040, 0.059 μM for HeLa, MCF7, U87 MG, T98G, HepG2, HCT8, HT-29 cells, respectively^[1].
Tubulin inhibitor 36 (Compound 10) (100 nM, 24 h, 48 h, 72 h) arrests mitotic and apoptosis in HeLa, MCF7, and U87 MG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:	HeLa, MCF7, U87 MG cells
Concentration:	100 nM
Incubation Time:	24 h
Result:	Arrested tubulin polymerization in HeLa, MCF7, and U87 MG cells.

Cell Cycle Analysis^[1]

Cell Line:	HeLa, MCF7, U87 MG cells
Concentration:	100 nM
Incubation Time:	24 h, 48 h, 72 h
Result:	Induced remarkable mitotic arrest in 24 h of HeLa cells. Induced mitotic arrest in 24 h of MCF7 cells but lower cell death compared to HeLa cells Induced remarkable mitotic arrest in 24 h of U87 MG cells and severe cell death.

Apoptosis Analysis^[1]

Cell Line:	HeLa, MCF7, U87 MG cells
Concentration:	100 nM
Incubation Time:	72 h
Result:	Induced nearly 73% of apoptosis in 72 h of HeLa cells and lower levels of MCF7 cells Induced lower cell death levels of MCF7 cells Displayed the highest cell death levels of d U87 MG cells

Molecular Weight

356.83

Formula

C₁₆H₁₃ClN₆S

SMILES

CN1C=CC2=C1C=CC(N3N=NN=C3C4=CC(Cl)=NC(SC)=C4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gallego-Yerga L, et al. Novel Tetrazole Derivatives Targeting Tubulin Endowed with Antiproliferative Activity against Glioblastoma Cells. Int J Mol Sci. 2023 Jul 4;24(13):11093. [Content Brief]