Tubulin polymerization-IN-81

Tubulin polymerization-IN-81 (Compound 4a) (10 μM) exhibits potent activity against fifteen cancer cell lines and is lethal to SF-539 and CAKI-1 with GI = 112.22 % and 150.64 %, respectively^[1].
Tubulin polymerization-IN-81 can inhibit the proliferation of various cell lines^[1].
Tubulin polymerization-IN-81 (6 μM, 20 min) has a tubulin inhibition activity with an IC₅₀ of 5.41 μM, hindering microtubule polymerization in A549 cells^[1].
Tubulin polymerization-IN-81 (5.93 μM, 48 h) prevents cancer cell proliferation by arresting the cell cycle at the G2/M phase in A549 cells (34.8%) ^[1].
Tubulin polymerization-IN-81 (5.93 μM, 48 h) displays significantly high levels of ROS generation and exhibits a 2.4 fold increase in A549 cells^[1].
Tubulin polymerization-IN-81 (5.93 μM, 48 h) induces 85% cell death of the total cells, mainly in the early stage in A549 cells^[1].
Tubulin polymerization-IN-81 (5.93 μM, 48 h) displays significant loss of MMP by approximately 56- 67 % in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.